Claims for Patent: 5,932,247
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Summary for Patent: 5,932,247
| Title: | Pharmaceutical composition for piperidinoalkanol compounds |
| Abstract: | The invention provides a pharmaceutical composition in solid unit dosage form, comprising, a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof; and, b) at least one inert ingredient. |
| Inventor(s): | Ortyl; Thomas T. (Overland Park, KS), Skultety; Paul F. (Leawood, KS), Mitchell; Kristen C. (Lee's Summit, MO), Phadke; Deepak S. (Olathe, KS), Attarchi; Faraneh (Kansas City, MO), Pierce; Marguerite L. (Fairway, KS), Schoeneman; Aaron W. (Lee's Summit, MO), Schnitz; Joseph M. (Kansas City, MO) |
| Assignee: | Hoechst Marion Roussel, Inc. (Cincinnati, OH) |
| Application Number: | 08/948,005 |
| Patent Claims: |
1. A pharmaceutical composition in solid unit dosage form prepared by a process comprising blending together a compound of the formula: ##STR10## wherein X is a number ranging
from about zero to 5, and the individual optical isomers thereof, with microcrystalline cellulose, lactose and pregelatinized starch; adding a solution of gelatin in water mixing; drying and milling the mixture; and adding croscarmellose sodium with
mixing, wherein the resulting mixture is filled into capsules.
2. A pharmaceutical composition in solid form wherein croscarmellose sodium, microcrystalline cellulose, lactose, pregelatinized starch, gelatin and magnesium stearate are present in amounts of about 4.8%, 33.7%, 33.7%, 9.6%, 3.5% and 0.5%, respectively, by weight of the composition, wherein the final mixture is pressed into a tablet from which the quantity of compound of the formula: ##STR11## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, dissolved in 45 minutes, is not less than 75% of label in water at about 37.degree. C. and about 50 rpm when measured using USP Apparatus 2. 3. A pharmaceutical composition in solid form wherein croscarmellose sodium, microcrystalline cellulose, lactose, pregelatinized starach, gelatin and magnesium stearate are present in amounts of about 4.8%, 25.7%, 25.7%, 9.6%, 3.5% and 0.75% respectively, by weight of the composition wherein the final mixture is pressed into a tablet from which the quantity of compound of the formula: ##STR12## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, dissolved in 45 minutes, is not less than 75% of label in 0.001 N aqueous hydrochloric acid at abaout 37.degree. C. and about 50 rpm when measured using USP Apparatus 2. 4. A pharmaceutical composition in solid form wherein croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, and magnesium stearate are present in amounts of about 6%, 33.3%, 30% and 0.75% respectively, by weight of the composition wherein the final mixture is pressed into a tabalet from which the quantity of compound of the formula: ##STR13## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, dissolved in 45 minutes, is not less than 75% of label in 0.001 N aqueous hydrochloric acid at about 37.degree. C. and about 50 rpm when measured using USP Apparatus 2. |
