Claims for Patent: 6,005,001
✉ Email this page to a colleague
Summary for Patent: 6,005,001
Title: | Pharmaceutical composition |
Abstract: | Non-greasy topical solutions, emulsion gels or lotions comprising as the active agent a compound of formula I ##STR1## and a lower alkanol, and if desired together with a solubilizing agent or an oil phase such as isopropyl myristate are useful delivery systems. |
Inventor(s): | Richter; Friedrich (Schonbuhl, CH), Steiger; Michel (Bern, CH) |
Assignee: | Novartis AG (formerly Sandoz AG) (Basel, CH) |
Application Number: | 09/181,651 |
Patent Claims: |
1. A topical pharmaceutical composition comprising as the active agent a compound of formula I ##STR3## a solubilizing agent and a lower alkanol.
2. A composition according to claim 1 containing water. 3. A composition according to claim 2 containing from 50 to 85% of water. 4. A composition according to claim 1 containing from 5 to 35% of a lower alkanol. 5. A composition according to claim 4 wherein the alkanol is ethanol. 6. A composition according to claim 1 which is substantially free of fatty material. 7. A composition claim 1 containing a surfactant being non-anionic. 8. A composition claim 1 for the treatment of fungal infections wherein the active agent is the compound of formula I as defined in claim 1 in free base form or in acid addition salt form, together with a solubilizing agent and excipients as appropriate. 9. A composition according to claim 8 which is a spray, a gel or a fluid gel. 10. A composition according to claim 8 wherein the solubilizing agent is a polyoxyethylene fatty alcohol ether. 11. A composition according to claim 8, wherein the ratio between the compound of formula I and the solubilizing agent is from about 1:0.5 to about 1:15. 12. A composition according to claim 1 wherein the active agent is the compound of formula I as defined in claim 1 in free base form or in acid addition salt form, together with an oil phase and further excipients as appropriate. 13. A composition according to claim 1 containing isopropyl myristate as an oil phase. 14. A composition according to claim 12, wherein the ratio between the compound of formula I and the oil phase is from about 1:5 to about 1:40 on a w/w basis. 15. A composition according to claim 1 wherein the compound of formula I is present from about 0.1% to about 5% of the total weight of the composition on a w/w basis. 16. A process for the preparation of a topical pharmaceutical composition according to claim 1 comprising working up a compound of formula I as defined in claim 1 together with a lower alkanol and adding further excipients as appropriate. 17. A method for the treatment of fungal infections comprising administering a pharmaceutically effective amount of a composition according to claim 1 to a patient in need of such treatment. |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.