Claims for Patent: 6,136,783

Summary for Patent: 6,136,783

Title:	Antifungal compositions
Abstract:	The invention is a pharmaceutical composition for intravenous administration to a patient comprising a) a pharmaceutically effective amount of a compound having the formula ##STR1## and the pharmaceutically acceptable salts thereof; b) a pharmaceutically acceptable amount of an excipient such as a bulking agent effective to form a lyophilized cake; and c) a pharmaceutically acceptable amount of acetate buffer effective to provide a pH of between about 4 and 7.
Inventor(s):	Neururkar; Maneesh J. (Lansdale, PA), Kaufman; Michael J. (New Hope, PA), Hunke; William A. (Harleysville, PA)
Assignee:	Merck & Co., Inc. (Rahway, NJ)
Application Number:	09/333,245
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,136,783
Patent Claims:	1. A method for treating an infection caused by Candida sp. in a patient which comprises administering intravenously to said patient an effective amount of a composition comprising 42 mg/ml of a compound having the formula ##STR9## or a pharmaceutically acceptable salt thereof, 25 mM of an acetate buffer, 30 mg/ml of sucrose, 20 mg/ml of mannitol, and water. 2. A method for treating an infection caused by Candida sp. in a patient which comprises administering intravenously to said patient an effective amount of a composition comprising 42 mg/ml of a compound having the formula ##STR10## or a pharmaceutically acceptable salt thereof, 50 mM of an acetate buffer, 30 mg/ml of sucrose, 20 mg/ml of mannitol, and water. 3. A method for treating an infection caused by Aspergillus sp. in a patient which comprises administering intravenously to said patient an effective amount of a composition comprising 42 mg/ml of a compound having the formula ##STR11## or a pharmaceutically acceptable salt thereof, 25 mM of an acetate buffer, 30 mg/ml of sucrose, 20 mg/ml of mannitol, and water. 4. A method for treating an infection caused by Aspergillus sp. in a patient which comprises administering intravenously to said patient an effective amount of a composition comprising 42 mg/ml of a compound having the formula ##STR12## or a pharmaceutically acceptable salt thereof, 50 mM of an acetate buffer, 30 mg/ml of sucrose, 20 mg/ml of mannitol, and water. 5. A method for treating or preventing an infection or condition caused by Pneumocystis carinii in a patient in need of such treatment or prevention which comprises administering intravenously to said patient a preventative or therapeutic amount of a composition comprising 42 mg/ml of a compound having the formula ##STR13## or a pharmaceutically acceptable salt thereof, 25 mM of an acetate buffer, 30 mg/ml of sucrose, 20 mg/ml of mannitol, and water. 6. A method for treating or preventing an infection or condition caused by Pneumocystis carinii in a patient in need of such treatment or prevention which comprises administering intravenously to said patient a preventative or therapeutic amount of a composition comprising 42 mg/ml of a compound having the formula ##STR14## or a pharmaceutically acceptable salt thereof, 50 mM of an acetate buffer, 30 mg/ml of sucrose, 20 mg/ml of mannitol, and water.