Claims for Patent: 6,143,326

Summary for Patent: 6,143,326

Title:	Oral pharmaceutical preparation containing ibandronat
Abstract:	The invention is directed to well-tolerated pharmaceutical compositions for oral application, containing ibandronate or a physiologically tolerable salt thereof as active substance, the administration form consisting of an active substance-containing inner portion enclosed in such fashion by a coat free of active substance that rapid release of the active substance takes place.
Inventor(s):	Mockel; Jorn (Heidelberg, DE), Gabel; Rolf-Dieter (Schwetzingen, DE), Woog; Heinrich (Laudenbach, DE)
Assignee:	Roche Diagnostics GmbH (Mannheim, DE)
Application Number:	09/147,149
Patent Claims:	1. A method of treating a bone disease in a patient in need thereof, comprising orally administering to the patient a pharmaceutical formulation comprising a tablet core containing about 0.1 to 100 mg of ibandronate and a coating which is free of ibandronate and has the following proportional composition: (a) about 51.425% by weight of methylhydroxypropylcellulose; (b) about 24.650% by weight of titanium dioxide; (c) about 15.000% by weight of polyethylene glycol; and (d) about 8.925% by weight of talc. 2. The method of claim 1, wherein the bone disease is related to a disorder in calcium metabolism. 3. The method of claim 1, wherein the bone disease is selected from the group consisting of hypercalcemia, osteoporosis, tumor osteolysis, and Paget's disease.