Claims for Patent: 6,166,197

Summary for Patent: 6,166,197

Title:	Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
Abstract:	Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position.
Inventor(s):	Cook; Phillip Dan (San Marcos, CA), Sanghvi; Yogesh S. (San Marcos, CA), Sprankle; Kelly G. (Vista, CA), Ross; Bruce S. (Carlsbad, CA), Griffey; Rich H. (Vista, CA)
Assignee:	ISIS Pharmaceuticals, Inc. (Carlsbad, CA)
Application Number:	08/398,901
Patent Claims:	1. An oligomeric compound comprising at least one monomeric sub-unit of structure I: ##STR4## wherein: X is amino; R is methyl; L is oxygen; Z is --O--CH.sub.3 ; and one of Q.sub.1 and Q.sub.2 is attached via a phosphorothioate linking moiety to a nucleotide, oligonucleotide, nucleoside, or oligonucleoside and the other of said Q.sub.1 and Q.sub.2, is a hydroxyl, a protected hydroxyl, an activated solid support, a nucleotide, an oligonucleotide, a nucleoside, an oligonucleoside, an oligo-nucleotide/nucleoside, an activated phosphate, a phosphate, an activated phosphite, or a phosphite; provided that said linking moiety is not a sulfamate group. 2. An oligomeric compound comprising at least one monomeric sub-unit of structure I: ##STR5## wherein: X is amino; R is methyl; L is oxygen; Z is O--R.sub.1 X.sub.1, where R.sub.1 is C.sub.1 -C.sub.6 alkyl, and X.sub.1 is H; and one of Q.sub.1 and Q.sub.2 is attached via a phosphorothioate linking moiety to a nucleotide, oligonucleotide, nucleoside, or oligonucleoside and the other of said Q.sub.1 and Q.sub.2, is a hydroxyl, a protected hydroxyl, an activated solid support, a nucleotide, an oligonucleotide, a nucleoside, an oligonucleoside, an oligo-nucleotide/nucleoside, an activated phosphate, a phosphate, an activated phosphite, or a phosphite; provided that said linking moiety is not a sulfamate group. 3. An oligomeric compound comprising at least one monomeric sub-unit of structure I: ##STR6## wherein: X is amino; R is methyl; L is oxygen; Z is O--R.sub.1 X.sub.1, where R.sub.1 is substituted C.sub.1 -C.sub.6 alkyl, and X.sub.1 is H; and one of Q.sub.1 and Q.sub.2 is attached via a phosphorothioate linking moiety to a nucleotide, oligonucleotide, nucleoside, or oligonucleoside and the other of said Q.sub.1 and Q.sub.2, is a hydroxyl, a protected hydroxyl, an activated solid support, a nucleotide, an oligonucleotide, a nucleoside, an oligonucleoside, an oligonucleotide/nucleoside, an activated phosphate, a phosphate, an activated phosphite, or a phosphite; provided that said linking moiety is not a sulfamate group.