Claims for Patent: 6,169,181

Summary for Patent: 6,169,181

Title:	Compounds useful to treat retroviral infections
Abstract:	The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. ##STR1## wherein R.sub.10 and R.sub.20 taken together are: ##STR2##
Inventor(s):	Romines; Karen Rene (Paw Paw, MI), Bundy; Gordon L. (Portage, MI), Schwartz; Theresa M. (Kalamazoo, MI), Tommasi; Ruben A. (Whitehouse Station, NJ), Strohbach; Joseph W. (Mendon, MI), Turner; Steven Ronald (Kalamazoo, MI), Thaisrivongs; Suvit (Kalamazoo, MI), Aristoff; Paul Adrian (Kalamazoo, MI), Johnson; Paul D. (Portage, MI), Skulnick; Harvey Irving (Kalamazoo, MI), Skaletzky; Louis L. (Kalamazoo, MI), Anderson; David John (Kalamazoo, MI), Morris; Joel (Kalamazoo, MI), Gammill; Ronald B. (Portage, MI), Luke; George P. (Lexington, MA)
Assignee:	Pharmacia & Upjohn Company (Kalamazoo, MI)
Application Number:	09/188,998
Patent Claims:	1. A compound of the formula I ##STR135## wherein R.sub.1 is H--; wherein R.sub.2 is a) C.sub.3 -C.sub.5 alkyl, b) phenyl-(CH.sub.2).sub.2 --, c) het-SO.sub.2 NH--(CH.sub.2).sub.2 --, d) cyclopropyl-(CH.sub.2).sub.2 --, e) F-phenyl-(CH.sub.2).sub.2 --, f) het-SO.sub.2 NH-phenyl-, or g) F.sub.3 C--(CH.sub.2).sub.2 --; or wherein R.sub.1 and R.sub.2 taken together are a double bond; wherein R.sub.3 is the moiety of formula X ##STR136## wherein R.sub.4 is a) phenyl, b) het, c) cyclopropyl, d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --, e) het-SO.sub.2 NH--, f) Br--, g) N.sub.3 --, or h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--; wherein R.sub.5 is --H; wherein R.sub.6 is a) R.sub.4 --(CH.sub.2).sub.n --CH(R.sub.8)--, b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --, c) C.sub.3 -C.sub.5 alkyl, d) phenyl-(CH.sub.2).sub.2 --, e) het-SO.sub.2 NH--(CH.sub.2).sub.2 --, f) (HOCH.sub.2).sub.3 C--NH--C(O)--NH--(CH.sub.2).sub.3 --, g) (HO.sub.2 C)(H.sub.2 N)CH--(CH.sub.2).sub.2 --C(O)--NH--(CH.sub.2).sub.3 --, h) piperazin-1-yl-C(O)--NH--(CH.sub.2).sub.3, i) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--(CH.sub.2).sub.3 --, j) cyclopropyl-(CH.sub.2).sub.2 --, k) F-phenyl-(CH.sub.2).sub.2 --, l) het-SO.sub.2 NH-phenyl, or m) F.sub.3 C--(CH.sub.2).sub.2 --; wherein n is zero (0), one (1) or two (2); wherein R.sub.7 is a) cyclopropyl, b) CH.sub.3 --CH.sub.2 --, or c) t-butyl; wherein R.sub.8 is a) --CH.sub.2 --CH.sub.3, or b) --CH.sub.2 -cyclopropyl; wherein R.sub.9 is a) --NR.sub.12 SO.sub.2 -het, b) --NR.sub.12 SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11, c) --CH.sub.2 --SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.1 1, or d) --CH.sub.2 --SO.sub.2 -het; wherein het is pyridinyl, imidazolyl, benzimidazolyl, quinolinyl, pyrimidinyl, pyrazinyl, pyrazolyl, thiazolyl, purinyl, tetrahydropyranyl or quinazolinyl; substituted by zero (0) or one (1) R.sub.10 ; wherein R.sub.10 is a) --CH.sub.3, b) --CN, c) --OH, d) --C(O)OC.sub.2 H.sub.5, e) --CF.sub.3, f) --NH.sub.2, or g) --C(O)--NH.sub.2 ; wherein R.sub.11 is a) --CN, b) --F, c) --OH, or d) --NO.sub.2 ; wherein R.sub.12 is a) --H, or b) --CH.sub.3 ; or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1 of the formula I ##STR137## wherein R.sub.1 is H--; wherein R.sub.2 is a) C.sub.3 -C.sub.5 alkyl, b) phenyl-(CH.sub.2).sub.2 --, or c) het-SO.sub.2 NH--(CH.sub.2).sub.2 --; or wherein R.sub.1 and R.sub.2 taken together are a double bond; wherein R.sub.3 is the moiety of formula X ##STR138## wherein R.sub.4 is a) phenyl, b) het, c) cyclopropyl, d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --, e) het-SO.sub.2 NH--, f) Br--, g) N.sub.3 --, or h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--; wherein R.sub.5 is --H; wherein R.sub.6 is a) R.sub.4 --(CH.sub.2).sub.n --CH(R.sub.8)--, b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --, c) C.sub.3 -C.sub.5 alkyl, d) phenyl-(CH.sub.2).sub.2 --, e) het-SO.sub.2 NH--(CH.sub.2).sub.2 --, f) (HOCH.sub.2).sub.3 C--NH--C(O)--NH--(CH.sub.2).sub.3 --, g) (HO.sub.2 C)(H.sub.2 N)CH--(CH.sub.2).sub.2 --C(O)--NH--(CH.sub.2).sub.3 --, h) piperazin-1-yl-C(O)--NH--(CH.sub.2).sub.3, or i) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--(CH.sub.2).sub.3 --; wherein n is zero (0), one (1) or two (2); wherein R.sub.7 is a) cyclopropyl, b) CH.sub.3 --CH.sub.2 --, or c) t-butyl; wherein R.sub.8 is a) --CH.sub.2 --CH.sub.3, or b) --CH.sub.2 -cyclopropyl; wherein R.sub.9 is a) --NR.sub.12 SO.sub.2 -het, b) --NR.sub.12 SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11, c) --CH.sub.2 -SO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11, or d) --CH.sub.2 --SO.sub.2 -het; wherein het is pyridinyl, imidazolyl, benzimidazolyl, quinolinyl, pyrimidinyl, pyrazinyl, pyrazolyl, thiazolyl, purinyl, tetrahydropyranyl or quinazolinyl; substituted by zero (0) or one (1) R.sub.10 ; wherein R.sub.10 is a) --CH.sub.3, b) --CN, c) --OH, or d) --C(O)OC.sub.2 H.sub.5 ; wherein R.sub.11 is a) --CN, b) --F, c) --OH, or d) --NO.sub.2 ; wherein R.sub.12 is a) --H, or b) --CH.sub.3 ; or a pharmaceutically acceptable salt thereof. 3. The compound of claim 2 wherein het is the following, substituted by zero (0) or one (1) R.sub.10, a) 2-pyridinyl, b) imidazol-2-yl, c) imidazol-4-yl, d) benzimidazol-2-yl, e) quinolin-8-yl, f) quinolin-2-yl, g) pyrimidin-2-yl, h) quinazolin-2-yl, i) purin-6-yl, j) thiazol-2-yl, k) thiazol-4-yl, l) 2-pyrazolyl, m) 2-pyrazinyl, n) tetrahydropyran-4-yl, or o) tetrahydropyran-3-yl. 4. The compound of claim 3 of the formula I ##STR139## wherein R.sub.1 is H--; wherein R.sub.2 is a) H.sub.3 C--(CH.sub.2).sub.2 --, b) phenyl-(CH.sub.2).sub.2 --, c) (CH.sub.3).sub.2 CH--CH.sub.2, or d) pentyl; or wherein R.sub.1 and R.sub.2 taken together are a double bond; wherein R.sub.3 is the moiety of formula X ##STR140## wherein R.sub.4 is a) phenyl, b) het, c) cyclopropyl, d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --, e) het-SO.sub.2 NH--, f) Br--, g) N.sub.3 --, or h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--; wherein R.sub.5 is --H; wherein R.sub.6 is a) R.sub.4 --(CH.sub.2).sub.n --CH(R.sub.8)--, b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --, c) H.sub.3 C--(CH.sub.2).sub.2 --, d) phenyl-(CH.sub.2).sub.2 --, e) (CH.sub.3).sub.2 CH--CH.sub.2 --, or f) pentyl; wherein n is zero (0), one (1) or two (2); wherein R.sub.7 is a) cyclopropyl, or b) CH.sub.3 --CH.sub.2 --; wherein R.sub.8 is a) --CH.sub.2 --CH.sub.3, or b) --CH.sub.2 -cyclopropyl; wherein R.sub.9 is a) --NHSO.sub.2 -het, or b) --NHSO.sub.2 -phenyl substituted by zero (0) or one (1) R.sub.11 ; wherein het is the following, substituted by zero (0) or one (1) R.sub.10, a) 2-pyridinyl, b) imidazol-2-yl, c) imidazol-4-yl, d) quinolin-8-yl, e) tetrahydropyran-4-yl, f) tetrahydropyran-3-yl, or g) benzimidazol-2-yl; wherein R.sub.10 is a) --CH.sub.3 ; wherein R.sub.11 is a) --CN, b) --F or c) --NO.sub.2 ; or a pharmaceutically acceptable salt thereof. 5. The compound of claim 4 of the formula VI ##STR141## wherein R.sub.2 is a) H.sub.3 C--(CH.sub.2).sub.2 --, b) phenyl-(CH.sub.2).sub.2 --, c) (CH.sub.3).sub.2 CH--CH.sub.2 --, or d) pentyl; wherein R.sub.3 is the moiety of formula X ##STR142## wherein R.sub.6 is a) H.sub.3 C--(CH.sub.2).sub.2 --, b) phenyl-(CH.sub.2).sub.2 --, c) (CH.sub.3).sub.2 CH--CH.sub.2 --, or d) pentyl; wherein R.sub.7 is a) CH.sub.3 --CH.sub.2 --, or b) cyclopropyl; wherein R.sub.9 is a) --NHSO.sub.2 -phenyl substituted by one (1) R.sub.11, or b) --NHSO.sub.2 -het; wherein het is the following, substituted by zero (0) or one (1) R.sub.10, a) imidazol-4-yl, or b) quinolin-8-yl; wherein R.sub.10 is --CH.sub.3 ; wherein R.sub.11 is a) --CN, or b) --F. 6. The compound of claim 4 of the formula VII ##STR143## wherein R.sub.3 is the moiety of formula X ##STR144## wherein R.sub.4 is a) phenyl, b) het, c) cyclopropyl, d) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --, e) het-SO.sub.2 NH--, f) Br--, g) N.sub.3 --, or h) HO.sub.3 S(CH.sub.2).sub.2 --N(CH.sub.3)--C(O)--(CH.sub.2).sub.6 --C(O)--NH--; wherein R.sub.6 is a) R.sub.4 --(CH.sub.2).sub.n --CH(R,)--, or b) H.sub.3 C--[O(CH.sub.2).sub.2 ].sub.2 --CH.sub.2 --; wherein R.sub.7 is cyclopropyl; wherein R.sub.8 is a) --CH.sub.2 --CH.sub.3, or b) --CH.sub.2 -cyclopropyl; wherein R.sub.9 is a) --NHSO.sub.2 -het, or b) --NHSO.sub.2 -phenyl substituted by one (1) R.sub.11 ; wherein n is zero (0), one (1) or two (2); wherein het is the following, substituted by zero (0) or one (1) R.sub.10, a) imidazol-4-yl, b) imidazol-2-yl, c) quinolin-8-yl, d) tetrahydropyran-3-yl, e) tetrahydropyran-4-yl, f) 2-pyridinyl, or g) benzimidazol-2-yl; wherein R.sub.10 is --CH.sub.3 ; wherein R.sub.11 is a) --NO.sub.2, b) --F, or c) --CN; or a pharmaceutically acceptable salt thereof. 7. The compound of claim 2 selected from the group consisting of: 3-[cyclopropyl[3-[(4-cyanophenylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6- (2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one; 3-[cyclopropyl[3-[(2-pyridinylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6-(2 -phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one; 3-[cyclopropyl[3-[(1-methyl-4-imidazolylsulfonyl)methyl]phenyl]methyl]-4-hy droxy-6-(2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one; 3-[cyclopropyl[3-[(5-cyano-2-pyridinylsulfonyl)methyl]phenyl]methyl]-4-hydr oxy-6-(2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one; 3-[cyclopropyl[3-[(2-benzimidazolylsulfonyl)methyl]phenyl]methyl]-4-hydroxy -6-(2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one; 3-[cyclopropyl[3-[(2-quinolinylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6-( 2-phenylethyl)-6-(1-propyl)-5,6-dihydro-2H-pyran-2-one; 4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran- 3-yl)-propyl]-phenyl]-benzenesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-8-quinolinesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl]-ph enyl]-8-quinolinesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5 ,6-dihydro-2H-pyran-3-yl)-propyl]-phenyl]-1-methyl-1H-imidazolesulfonamide ; 4-Fluoro-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-p ropyl]-phenyl]-benzenesulfonamide; 4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-benzenesulfonamide; N-[3-[1-(4-hydroxy-6,6-diisobutyl-2-oxo-5,6-dihydro-2H-pyran-3-yl)-propyl]- phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclo-prop ylmethyl]-phenyl]-1-methyl-1H-imidazolesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclo-prop ylmethyl]-phenyl]-8-quinolinesulfonamide; 4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cy clopropylmethyl]-phenyl]-benzenesulfonamide; 4-Fluoro-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-c yclopropylmethyl]-phenyl]-benzenesulfonamide; (R or S)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-8-quinolinesulfonamide; (R or S)-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; (S or R)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-8-quinolinesulfonamide; (S or R)-N-[3-[1-(4-hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-propyl ]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; (R or S)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclop ropylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; (S or R)-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipropyl-5,6-dihydro-2H-pyran-3-yl)-cyclop ropylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; 4-Cyano-N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran- 3-yl)-cyclopropylmethyl]-phenyl]-benzenesulfonamide; 4-Fluoro-N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran -3-yl)-cyclopropylmethyl]-phenyl]-benzenesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-cy clopropylmethyl]-phenyl]-8-quinolinesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-cy clopropylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-cyclopr opylmethyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipentyl-5,6-dihydro-2H-pyran-3-yl)-propyl]-ph enyl]-1-methyl-1H-imidazole-4-sulfonamide; 4-Cyano-N-[3-[1-(4-Hydroxy-2-oxo-6,6-dipentyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-benzenesulfonamide; N-[3-[1(R or S)-(6(R or S)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[1(R or S)-(6(S or R)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[1(S or R)-(6(R or S)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[1(S or R)-(6(S or R)-4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-[t-Butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3- yl)-methyl]-phenyl]-1-methyl-1H-imidazole-4-sulfonamide; 4-Cyano-N-[3-[t-butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H- pyran-3-yl)-methyl]-phenyl]-benzenesulfonamide; 4-Fluoro-N-[3-[t-butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H -pyran-3-yl)-methyl]-phenyl]-benzenesulfonamide; N-[3-[t-Butyl-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3- yl)-methyl]-phenyl]-8-quinolinesulfonamide; N-[3-[1-(6-(2-(1-Methyl-1H-imidazole-4-sulfonylamino)-ethyl)-4-hydroxy-2-ox o-6-propyl-5,6-dihydro-2H-pyran-3-yl)-propyl]-phenyl]-1-methyl-1H-imidazole -4-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-pyridinesulfonamide; 4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl) -propyl]-phenyl]-2-pyridinesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-quinolinesulfonamide; 2-Hydroxy-N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-y l)-propyl]-phenyl]-benzenesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-pyrimidinesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-2-quinazolinesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-7H-purine-6-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1H-imidazole-2-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-1H-benzimidazole-2-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-thiazole-4-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-pyridinesulfonamide; 4-Cyano-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran- 3-yl)-propyl]-phenyl]-2-pyridinesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-quinolinesulfonamide; 2-Hydroxy-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyra n-3-yl)-propyl]-phenyl]-benzenesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-pyrimidinesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-2-quinazolinesulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-7H-purine-6-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-1H-imidazole-2-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-1H-benzimidazole-2-sulfonamide; N-[3-[1-(4-Hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)-pr opyl]-phenyl]-thiazole-4-sulfonamide; 4-Fluoro-N-[3-[1-(4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran -3-yl)-propyl]-phenyl]-benzenesulfonamide; 5-cyano-N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl) -propyl]-phenyl]-N-methyl-2-pyridinesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-quinolinesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-imidazolesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-pyrimidinesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-benzimidazolesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-quinazolinesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -5 phenyl]-N-methyl-6-purinesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-4-thiazolesulfonamide; N-[3-[1-(4-hydroxy-2-oxo-6,6-diphenethyl-5,6-dihydro-2H-pyran-3-yl)-propyl] -phenyl]-N-methyl-2-pyridinesulfonamide; N-[3-(1-[5,6-Dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-propyl-2H-pyran-3-yl ]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-(1(S)-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-(1(R)-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-(1(S)-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-(1(R)-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl)-6-propyl-2H-pyra n-3-yl]-2,2-dimethylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-2,2-dimeth ylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-2,2-dimeth ylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide; 5-Cyano-N-[3-(1-[5,6-dihydro-4-hydoxy-2-oxo-6-(2-phenethyl)-6-propyl-2H-pyr an-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-phenethyl-6-propyl-2H-pyran-3-yl)pro pyl}phenyl]-5-cyanopyridine-2-sulfonamide; and N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl}phen yl]-5-cyanopyridine-2-sulfonamide. 8. The compound of claim 2 selected from the group consisting of: 3-[cyclopropyl[3-[(4-cyanophenylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6- [1-(phenylmethyl)propyl]-2H-pyran-2-one; 3-[cyclopropyl[3-[(2-pyridinylsulfonyl)methylphenylmethyl]-4-hydroxy-6-[1-( phenylmethyl)propyl]-2H-pyran-2-one; 3-[cyclopropyl[3-[(1-methyl-4-imidazolylsulfonyl)methyl]phenyl]methyl)-4-hy droxy-6-[1-(phenylmethyl)propyl]-2H-pyran-2-one; 3-[cyclopropyl[3-[(5-cyano-2-pyridinylsulfonyl)methyl]phenyl]methyl]-4-hydr oxy-6-[1-(phenylmethyl)propyl]-2H-pyran-2-one; 3-[cyclopropyl[3-[(2-benzimidazolylsulfonyl)methyl]phenyl]methyl]-4-hydroxy -6-[1-(phenylmethyl)propyl]-2H-pyran-2-one; 3-[cyclopropyl[3-[(2-quinolinylsulfonyl)methyl]phenyl]methyl]-4-hydroxy-6-[ 1-(phenylmethyl)propyl]-2H-pyran-2-one; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-4-fluoro-benzenesulfonamide; 4-Cyano-N-(3-{cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hy droxy-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-8-quinolinesulfonamide; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl]-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; (R or S)-N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydrox y-2-oxo-2H-pyran-3-yl]-methyl]-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; (R or S)-N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydrox y-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl]-phenyl)-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-benzoimidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(2-cyclopropyl-1-cyclopropylmethyl-ethyl)-4-hydroxy-2- oxo-2H-pyran-3-yl]-methyl}-phenyl)-2-quinolinesulfonamide; N-(3-{(Cyclopropyl-[4-hydroxy-6-(3-{2-methoxy-ethoxy}-propyl)-2-oxo-2H-pyra n-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-{Cyclopropyl-[6-(1-ethyl-3-{2-methoxy-ethoxy}-propyl)-4-hydroxy-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; 4-Cyano-N-(3-{cyclopropyl-[6-(1-ethyl-3-{2-methoxy-ethoxy}-propyl)-4-hydrox y-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethyl-3-{1-methyl-1H-imidazole-4-sulfonylamino}-pro pyl)-4-hydroxy-2-oxo-2H-pyran-3-yl-methyl}-phenyl)-1-methyl-H-imidazole-4-s ulfonamide; N-(3-{[6-(3-Bromo-1-ethyl-propyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-cyclopropy l-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-{[6-(3-Azido-1-ethyl-propyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-cyclopropy l-methyl)-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; 2-[[8-[[3-[3-[Cyclopropyl[3-[[(1-methyl-1H-imidazol-4-yl)sulfonyl]aminolphe nyl]methyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]pentyl]amino]-1,8-dioxooctyl]meth ylamino]-ethane sulfonic acid, monosodium salt; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-[(2-hydroxy-1,1-bisfhydroxymethyl}-ethyl) -amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzen esulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl )-amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-2-pyr idinesulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{(2-hydroxy-1,1-bisthydroxymethyl}-ethyl) -amino-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-imid azole-2-sulfonamide; N-(3-Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl) -amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-ben zoimidazole-2-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl )-amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-met hyl-1H-imidazole-4-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[(2-hydroxy-1,1-bis{hydroxymethyl}-ethyl )-amino]-carbonyl}-amino-propyl)-2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-met hyl-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1H-benzoimidazole-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{.gamma.-L-glutamyl}-amino-propyl)-2-oxo- 2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-benzenesulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1H-benzoimidazole-2-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-{Cyclopropyl-[4-hydroxy-6-(3-{[piperazin-1-yl]-carbonyl}-amino-propyl) -2-oxo-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide; 2-[[8-[[3-[3-[Cyclopropyl[3-[[phenylsulfonyl]amino]phenyl]methyl]-4-hydroxy -2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methylamino]-ethanesulfon ic acid, monosodium salt; 2-[[8-[[3-[3-[Cyclopropyl[3-[[(2-pyridyl)sulfonyl]amino]phenyl]methyl]-4-hy droxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methylamino]-ethane sulfonic acid, monosodium salt; 2-[[8-[[3-[3-[Cyclopropyl[3-[[(1H-benzimidazol-2-yl)sulfonyl]amino]phenyl]m ethyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methyl amino]-ethanesulfonic acid, monosodium salt; 2-[[8-[[3-[3-[Cyclopropyl[3-[[(1H-imidazol-2-yl)sulfonyl]amino]phenyl]methy l]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]methylamino]- ethane sulfonic acid, monosodium salt; 2-[[8-[[3-[3-[Cyclopropyl[3-[[(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]phe nyl]methyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]meth ylamino]-ethanesulfonic acid, monosodium salt; 2-[[8-[[3-[3-[Cyclopropyl[3-[[(1-methyl-1H-imidazol-2-yl)sulfonyl]amino]phe nyl]methyl]-4-hydroxy-2-oxo-2H-pyran-6-yl]propyl]amino]-1,8-dioxooctyl]meth ylamino]-ethane sulfonic acid, monosodium salt; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(S)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(S)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-4-sulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-2-pyridinesulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-2-pyridinesulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-1-methyl-1H-imidazole-2-sulfonamide; N-(3-[Cyclopropyl[4-hydroxy-2-oxo-6-[1-[(tetrahydro-2H-pyran-3-yl)methyl]pr opyl]-2H-pyran-3-yl]methyl]phenyl]-8-quinolinesulfonamide; N-(3-[Cyclopropyl[4-hydroxy-2-oxo-6-[1-[(tetrahydro-2H-pyran-3-yl)methyl]pr opyl]-2H-pyran-3-yl]methyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-(3-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]- methyl}-phenyl)-benzimidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]- methyl}-phenyl)-1H-imidazole-2-sulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-4-cyanobenzenesulfonamide; N-(3-(R or S)-{Cyclopropyl-[6-(1-(R)-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-m ethyl}-phenyl)-4-cyanobenzenesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-4-nitrobenzenesulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-4-cyano-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-quinolinesulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-hydroxybenzenesulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-pyrazolesulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-2-quinazolinesulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-7H-purine-6-sulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-benzimidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-thiazole-4-sulfonamide; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-4-ethoxycarbonyl-1H-imidazole-2-sulfaonami de; N-(3-{Cyclopropyl-[6-(1-(tetrahydropyran-4-ylmethyl)-propyl)-4-hydroxy-2-ox o-2H-pyran-3-yl]-methyl}-phenyl)-3-hydroxy-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-4-cyano-2-pyridinesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-2-quinolinesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-2-hydroxybenzenesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-ethy l}-phenyl)-2-pyrazolesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-ethy l}-phenyl)-2-quinazolinesulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-ethy l}-phenyl)-7H-purine-6-sulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-1H-imidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-benzimidazole-2-sulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-thiazole-4-sulfonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-4-ethoxycarbonyl-1H-imidazole-2-sulfaonamide; N-(3-{Cyclopropyl-[6-(1-ethylphenethyl)-4-hydroxy-2-oxo-2H-pyran-3-yl]-meth yl}-phenyl)-3-hydroxy-2-pyridinesulfonamide; 5-cyano-N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-p yrone]-N-methyl-2-pyridinesulfonamide; N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyronel-N -methyl-2-quinolinesulfonamide; N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-imidazolesulfonamide; N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-pyrimidinesulfonamide; N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-benzimidazolesulfonamide; N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyronel-N -methyl-2-quinazolinesulfonamide; N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-6-purinesulfonamide; N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-4-thiazolesulfonamide; and N-[6-(1'-benzylpropyl)-4-hydroxy-3-(1'-cyclopropylmethylphenyl)-2-pyrone]-N -methyl-2-pyridinesulfonamide. 9. The compound of claim 1 of the formula VI ##STR145## wherein R.sub.2 is a) H.sub.3 C--CH.sub.2 --, b) H.sub.3 C--(CH.sub.2).sub.2 --, c) cyclopropyl-(CH.sub.2).sub.2 --, d) F-phenyl-(CH.sub.2).sub.2 --, e) het-SO.sub.2 NH-phenyl-, f) (H.sub.3 C).sub.2 HC--CH.sub.2, g) phenyl-(CH.sub.2).sub.2 --, or h) F.sub.3 C--(CH.sub.2).sub.2 --; wherein R.sub.3 is the moiety of formula X ##STR146## wherein R.sub.6 is a) H.sub.3 C--CH.sub.2 --, b) H.sub.3 C--(CH.sub.2).sub.2 --, c) cyclopropyl-(CH.sub.2).sub.2 --, d) F-phenyl-(CH.sub.2).sub.2 --, e) het-SO.sub.2 NH-phenyl, f) (H.sub.3 C).sub.2 HC--CH.sub.2, g) phenyl-(CH.sub.2).sub.2 --, or h) F.sub.3 C--(CH.sub.2).sub.2 --; wherein R.sub.7 is a) H.sub.3 C--CH.sub.2 --, b) t-butyl, or c) cyclopropyl wherein R.sub.9 is a) --NHSO.sub.2 -het, or b) --NHSO.sub.2 -phenyl substituted by one (1) R.sub.1 l; wherein het is the following, substituted by zero (0) or one (1) R.sub.10, a) imidazol-4-yl, b) 2-pyridinyl, or c) quinolin-8-yl; wherein R.sub.10 is, a) --CH.sub.3, b) --CN, c) --CF.sub.3, d) --NH.sub.2, or e) --C(O)--NH.sub.2 ; wherein R.sub.11 is CN. 10. The compound of claim 9 selected from the group consisting of: N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-(l-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-(1-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]propyl)phenyl]-5-cyano-2-pyridinesulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamid e; N-(3-[1-(6-Ethyl-5,6-dihydro-4-hydroxy-6-[3-([(l-methyl-1H-imidazol-4-yl)su lfonyl]amino)phenyl]-2-2H-pyran-3-yl)propyl]phenyl)-1-methyl-1H-imidazole-4 -sulfonamide; 5-Cyano-N-(3-[1-(6-[3-([(5-cyano-2-pyridinyl)sulfonyl]amino)phenyl]-6-ethyl -5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-yl)propyl]phenyl)-2-pyridinesulfona mide; N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-(1-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]-2,2-dimethyl-propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-(1-[6,6-Bis-(2-cyclopropyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran -3-yl]-2,2-dimethyl-propyl)phenyl]-5-cyano-2-pyridinesulfonamide, 5-cyano-N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R or S)-(3,3,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyr idinesulfonamide, 5-cyano-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide, 5-cyano-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide, 5-cyano-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide, 5-cyano-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide, N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(R or S)-(2-phenethyl)-6-(3,3,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylprop yl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(R)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide, N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(S)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide, N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(S)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide, N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(R)-(2-phenethyl)-6-(3,3,3-trifl uoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole -4-sulfonamide, 5-amino-N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R or S)-(3,3,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyr idinesulfonamide, 5-amino-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide, 5-amino-N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide, 5-amino-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-(3,3 ,3-trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesul fonamide, 5-amino-N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-(3,3 ,3trifluoropropyl)-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulf onamide, N-[3-(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-[6-(R or S)-propyl]-2H-pyran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide , N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide, N-[3-(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide, N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(R)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide, N-[3-(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-(S)-propyl-2H-py ran-3-yl]-2,2-dimethylpropyl]phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-p yran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-propyl]- phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-propyl]- phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-2,2-dime thylpropyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]1-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]1-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro-2H-pyran-3-yl]-propyl] -phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro-2H-pyran-3-yl]-propyl] -phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-phenethyl-5,6-dihydro -2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-2,2-dime thylpropyl]-phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonamide, 4-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenethyl)-6-n- propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonami de, 5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 4-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfonami de, 4-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 4-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 4-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 4-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl]-phenyl]-2-pyridinesulfon amide, 5-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridine sulfonamide, 5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3-(1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H- pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3(R or S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-py ridine-sulfonamide, 5-Cyano-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3-(1-[5,6-dihydro-6,6-diisobutyl-4-hydroxy-2-oxo-2H-pyran-3-yl]p ropyl)phenyl]-2-pyridinesulfonamide, N-[3-(1-[5,6-Dihydro-6,6-diisobutyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dime thylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, 5-Cyano-N-[3-(1-[5,6-dihydro-6,6-diisobutyl-4-hydroxy-2-oxo-2H-pyran-3-yl]- 2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, N-[3(R or S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R or S)-[2-phenylethyl]-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl]-1-me thyl-1H-imidazole-4-sulfonamide, N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide, 5-Cyano-N-[3-(1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H- pyran-3-yl]cyclopropylmethyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(R or S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-py ridine-sulfonamide, 5-Amino-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(R or S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfona mide, 5-Amino-N-[3(R)-(-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-propy l-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(R)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(S)-(1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenylethyl)-6-prop yl-2H-pyran-3-yl]propyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(R or S)-(1-[6(R or S)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2-oxo-6-propyl-2H-pyran -3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridine-sulfonamide, 5-Amino-N-[3(R)-(1-[6(R)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2o xo-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide , 5-Amino-N-[3(R)-(1-[6(S)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2- oxo-6-propyl-2H-pyran-3-yl-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide , 5-Amino-N-[3(S)-(1-[6(R)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2- oxo-6-propyl-2H-pyran-3-yl-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide , 5-Amino-N-[3(S)-(1-[6(S)-(2-[4-fluorophenyl]ethyl)-5,6-dihydro-4-hydroxy-2- oxo-6-propyl-2H-pyran-3-yl]-2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamid e, N-[3(R or S)-(1-[5,6-Dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dimethy lpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(R)-(-[5,6-Dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dime thylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(S)-(-[5,6-Dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dime thylpropyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, 5-Amino-N-[3(R or S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dimethy lpropyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(R)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Amino-N-[3(S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3(R or S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl]-2,2-dimethy lpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3(R)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, 5-Cyano-N-[3(S)-(1-[5,6-dihydro-6,6-dipropyl-4-hydroxy-2-oxo-2H-pyran-3-yl] -2,2-dimethylpropyl)phenyl]-2-pyridinesulfonamide, N-[3(R or S)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-yl]pr opyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(R)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-y l]propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(S)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-y l]propyl)phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3(R or S)-(1-[6,6-Bis(2-phenylethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3-yl]pr opyl)phenyl]-5-cyano-2-pyridinesulfonamide, N-[3(R)-(1-[6,6-Bis(2-phenyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3- yl]propyl)phenyl]-5-cyano-2-pyridinesulfonamide, N-[3(S)-(1-[6,6-Bis(2-phenyl-ethyl)-5,6-dihydro-4-hydroxy-2-oxo-2H-pyran-3- yl]propyl)phenyl]-5-cyano-2-pyridinesulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-4-cyanobenzenesulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-8-quinolinesulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)p ropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)p ropyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6-(2-(4-fluorophenyl)ethyl)-6-propyl-2 H-pyran-3-yl)propyl}phenyl]-5-carbamoylpyridine-2-sulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-(4-fluorophenyl)ethyl)-2H-py ran-3-yl)propyl}phenyl]-5-carbamoylpyridine-2-sulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl}phen yl]-5-carbamoylpyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-phenethyl-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfo namide, N-[3-1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3-y l)propyl]phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-phenethyl-6-propyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4 -sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)- 2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)- 2,2-dimethylpropyl]phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl}ph enyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl]-5-cyanopyridine-2-sulfonamid e, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl]-5-cyanopyridine-2-sulfonamid e, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl,phenyl]-5-cyanopyridine-2-sulfonamid e, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamid e, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl}ph enyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulf onamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2- dimethylpropyl}phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2- dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-yl)-2,2- dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-bis(2-phenylethyl)-2H-pyran-3-y l)-2,2-dimethylpropyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl}phenyl} -5-cyanopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl}phenyl] -5-aminopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-cyano pyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)propyl}phenyl]-1-methy l-1H-imidazole-4-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-1-methyl-1H-imidazole-4-sulfonamide, N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-(2-(4-fluorophenyl)ethyl)-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-amino pyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-(2-(4-fluorophenyl)ethyl)-6-pr opyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide, N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-(2-(4-fluorophenyl)ethyl)-6-5 propyl-2H-pyran-3-yl)propyl}phenyl]-5-aminopyridine-2-sulfonamide, N-[3-[1-(S)-[5,6,-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyr an-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide (3S,6R)-N-[3-[1-[5,6,-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H -pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide (3S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl ]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propyl ]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran-3- yl)propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (3R,6S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran- 3-yl)propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (3S,6S)-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H- pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide. 11. The compound of claim 9 wherein R.sub.2 is a) H.sub.3 C--(CH.sub.2).sub.2 --, or b) phenyl-(CH.sub.2).sub.2 --; wherein R.sub.3 is the moiety of formula X; wherein R.sub.6 is a) H.sub.3 C--(CH.sub.2).sub.2 --, or b) phenyl-(CH.sub.2).sub.2 --; wherein R.sub.7 is a) H.sub.3 C--CH.sub.2 --, or b) t-butyl; wherein R.sub.9 is --NHSO.sub.2 -het; wherein het is the following, substituted by one (1) R.sub.10, a) imidazol-4-yl, or b) 2-pyridinyl; wherein R.sub.10 is, a) --CH.sub.3, b) --CN, or c) --CF.sub.3. 12. The compound of claim 11 selected from the group consisting of: 5-Trifluoromethyl-N-[3-(R or S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro-2H-pyran-3-yl]-propyl]- phenyl]-2-pyridinesulfonamide; 5-Trifluoromethyl-N-[3-(R)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propy l]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide 5-Trifluoromethyl-N-[3-(S)-[1-[4-hydroxy-2-oxo-6,6-di-n-propyl-5,6-dihydro- 2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6,6-dipropyl-2H-pyran-3-yl)propy l]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide 5-Trifluoromethyl-N-[3(R or S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R or S)-(2-phenethyl)-6(R or S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridine sulfonamide; 5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; 5-Trifluoromethyl-N-[3(R)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3R,6S)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran -3-yl)propy]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide 5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(R)-(2-phenethyl )-6(R)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3S,6R)-N-[3-[1-[5,6,-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2 H-pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide 5-Trifluoromethyl-N-[3(S)-[1-[5,6-dihydro-4-hydroxy-2-oxo-6(S)-(2-phenethyl )-6(S)-n-propyl-2H-pyran-3-yl]-propyl]-phenyl]-2-pyridinesulfonamide; or (3S,6S)-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H -pyran-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide N-[3-[1-(S)-[5,6,-Dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyr an-3-yl]propyl]phenyl]-5-(triflouromethyl)-2-pyridinesulfonamide (3R)-N-[3-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6-propyl-6-phenethyl-2H-pyran-3-y l)propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide N-[3(R or S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R or S)-[2-phenylethyl]-6-propyl-2H-pyran-3-yl)-2,2-dimethylpropyl]phenyl)-1-me thyl-1H-imidazole-4-sulfonamide; N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3(R)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(R)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3(S)-[1-(5,6-Dihydro-4-hydroxy-2-oxo-6(S)-[2-phenylethyl]-6-propyl-2H-py ran-3-yl)-2,2-dimethylpropyl]phenyl]-1-methyl-1H-imidazole-4-sulfonamide; N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl}phenyl] -5-cyanopyridine-2-sulfonamide; N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6,6-dipropyl-2H-pyran-3-yl)-propyl} phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-{1(R or S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R or S)-phenethyl-6-propyl-2H-pyran-3-yl)propyl}phenyl]-5-cyanopyridine-2-sulfo namide; N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-{1(R)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide; N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(R)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide; and N-[3-{1(S)-(4-Hydroxy-5,6-dihydro-2-oxo-6(S)-phenethyl-6-propyl-2H-pyran-3- yl)propyl}phenyl]-5-cyanopyridine-2-sulfonamide.