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Last Updated: March 30, 2025

Claims for Patent: 6,488,960

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Summary for Patent: 6,488,960

Title:	Corticosteroid formulation
Abstract:	The present invention pertains to a unit dose formulation comprising 0.25 to 2 mg of a corticosteroid. This small dose can be used to treat rheumatoid arthritis, especially if adapted to release at least 90% by weight of the corticosteroid, 2 to 8 hours after administration.
Inventor(s):	Bardsley; Hazel Judith (Cambridge, GB)
Assignee:	Arakis Ltd. (GB)
Application Number:	09/936,586
Patent Claims:	1. A controlled-release formulation comprising from 0.25 mg to 2 mg of a corticosteroid selected from the group consisting of prednisone, methylprednisolone, and prednisolone, wherein said formulation is adapted to release at least 90% by weight of the corticosteroid 2 hours to 8 hours after administration. 2. The formulation according to claim 1, which comprises from 0.5 mg to 2 mg of the corticosteroid. 3. The formulation according to claim 1, which comprises from 1 mg to 1.25 mg of the corticosteroid. 4. The formulation according to claim 1, wherein the corticosteroid is prednisolone. 5. A method for the treatment of rheumatoid arthritis, wherein said method comprises administering to a patient an effective amount of a controlled-release formulation comprising from 0.25 mg to 2 mg of a corticosteroid selected from the group consisting of prednisone, methylprednisolone, and prednisolone, wherein said formulation is adapted to release at least 90% by weight of the corticosteroid 2 hours to 8 hours after administration. 6. The method according to claim 5, wherein the formulation comprises from 0.5 mg to 2 mg of the corticosteroid. 7. The method according to claim 5, wherein the formulation comprises from 1 mg to 1.25 mg of the corticosteroid. 8. The method according to claim 5, wherein the corticosteroid is prednisolone.

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