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Last Updated: April 15, 2025

Claims for Patent: 6,620,847

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Summary for Patent: 6,620,847

Title:	Copolymer-1 improvements in compositions of copolymers
Abstract:	The present invention relates to an improved composition of copolymer-1 comprising copolymer-1 substantially free of species having a molecular weight of over 40 kilodaltons.
Inventor(s):	Konfino; Eliezer (Ramat Gan, IL), Sela; Michael (Rehovot, IL), Teitelbaum; Dvora (Rehovot, IL), Arnon; Ruth (Rehovot, IL)
Assignee:	Yeda Research and Development Co., Ltd. (Rehovot, IL)
Application Number:	10/014,477
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,620,847
Patent Claims:	1. Copolymer-1 having a molecular weight of about 4 to about 9 kilodaltons, made by a process comprising: treating trifluoroacetyl copolymer-1 with aqueous piperidine to form a solution of copolymer-1; and purifying copolymer-1, thereby producing copolymer-1 having a molecular weight of about 4 to about 9 kilodaltons. 2. Copolymer-1 made by the process of claim 1, wherein the process further comprises reacting protected copolymer-1 with hydrobromic acid to form trifluoroacetyl copolymer-1. 3. Copoloymer-1 made by the process of claim 2, wherein the hydrobromic acid comprises about 33% hydrogen bromide in acetic acid. 4. Copolymer-1 made by the process of claim 2, wherein the process further comprises polymerizing N-carboxyanhydride derivatives to form protected copolymer-1. 5. Copolymer-1 made by the process of claim 4, wherein the polymerizing step comprises providing a diethylamine initiator. 6. Copoloymer-1 made by the process of claim 1, wherein the process further comprises adding acetic acid subsequent to the treating step. 7. Copoloymer-1 made by the process of claim 1, wherein the purfying step comprises filtration. 8. A method of manufacturing trifluoroacetyl copolymer-1 having a predetermined molecular weight profile, comprising the steps of: selecting a predetermined molecular weight profile, and then reacting protected copolymer-1 with hydrobromic acid at about 26.degree. C. for a time predetermined by test reaction to provide trifluoroacetyl copolymer-1 having the predetermined molecular weight profile. 9. The method of claim 7, further comprising a step of treating the trifluoroacetyl copoloymer-1 having the predetermined molecular weight profile with aqueous peperidine solution to form copolymer-1 having the predetermined molecular weight profile.

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