Claims for Patent: 6,693,115

Summary for Patent: 6,693,115

Title:	Acid addition salts of hydropyridine derivatives
Abstract:	Acid addition salts of 2-acetoxy-5-(.alpha.-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahyd rothieno[3,2-c]-pyridine. The acid addition salts of tetrahydrothienopyridine derivatives of the present invention exhibit excellent oral absorption, metabolization into the active compound, and platelet aggregation-inhibiting effects, low toxicity, and excellent storage and handling stabilities, and are useful as medicaments, preferably preventive or therapeutic agents (particularly therapeutic agents) for diseases caused by a thrombus or an embolus, still more preferably preventive or therapeutic agents (particularly therapeutic agents) for thrombosis or embolism.
Inventor(s):	Asai; Fumitoshi (Tanashi, JP), Ogawa; Taketoshi (Tokyo, JP), Naganuma; Hideo (Tokyo, JP), Yamamura; Naotoshi (Nishitokyo, JP), Inoue; Teruhiko (Ube, JP), Nakamura; Kazuyoshi (Onoda, JP)
Assignee:	Sankyo Company, Limited (Tokyo, JP) Ube Industries Ltd. (Ube, JP)
Application Number:	10/329,629
Patent Claims:	1. 2-Acetoxy-5-(.alpha.-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydr othieno[3,2-c]pyridine hydrochloride. 2. 2-Acetoxy-5-(.alpha.-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydr othieno[3,2-c]pyridine maleate. 3. A medicament composition comprising a pharmaceutically effective amount of the salt according to claim 1 as an active ingredient in combination with a pharmaceutically acceptable carrier. 4. A medicament composition comprising a pharmaceutically effective amount of the salt according to claim 2 as an active ingredient in combination with a pharmaceutically acceptable carrier. 5. The medicament composition according to claim 3, wherein said medicament is for prevention or treatment of a thrombus formation-induced or an embolization-induced disease in a warm blooded animal. 6. The medicament composition according to claim 4, wherein said medicament is for prevention or treatment of a thrombosis or an embolism in a human. 7. The medicament composition according to claim 6, wherein said medicament is for treatment of a thrombosis or an embolism in a human. 8. A method for prevention or treatment of a thrombus formation-induced or an embolization-induced disease in a warm blooded animal which comprises administering an effective amount of the salt according to claim 1. 9. The method according to claim 8, wherein the warm blooded animal is a human. 10. The method according to claim 9, wherein the method is for treatment of a thrombosis. 11. The method according to claim 9, wherein the method is for treatment of an embolism. 12. A method for prevention or treatment of a thrombus formation-induced or an embolization-induced disease in a warm blooded animal which comprises administering an effective amount of the salt according to claim 2. 13. The method according to claim 12, wherein the warm blooded animal is a human. 14. The method according to claim 13, wherein the method is for treatment of a thrombosis. 15. The method according to claim 13, wherein the method is for treatment of an embolism.