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Last Updated: April 2, 2025

Claims for Patent: 6,696,430

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Summary for Patent: 6,696,430

Title:	Use of vital dye for facilitating surgical procedures for vitreo-retinal surgery
Abstract:	A method for performing retinal membrane removal is disclosed using vital dyes which are applied to the membrane. Compositions including vital dyes which are useful in the retinal membrane removal methods are also disclosed.
Inventor(s):	Melles; Gerrit Reinold Jacob (Rotterdam, NL)
Assignee:
Application Number:	09/708,977
Patent Claims:	1. A method of removing a retinal disorder membrane from an inner surface of a retina comprising the steps of: surgically opening an eye; applying a vital dye onto the retinal disorder membrane located at an inner surface of the retina relative to vitreous to produce a stained retinal disorder membrane such that the retinal disorder membrane is stained without substantially staining internal limiting membrane of the retina or retinal layers underlying the internal limiting membrane compared to the stained retinal disorder membrane; and surgically removing the stained retinal disorder membrane from the inner surface of the retina. 2. A method according to claim 1, wherein the retinal disorder membrane is formed by proliferative vitreoretinopathy. 3. A method according to claim 1, wherein the retinal disorder membrane is an epiretinal membrane. 4. A method according to claim 1, wherein the method is part of a vitreo-retinal surgical procedure. 5. A method according to claim 1, wherein the dye is capable of staining tissue without substantially diffusing through said tissue. 6. The method according to claim 1, wherein the vital dye is selected from the group consisting of trypan blue, trypan red, brilliant crysyl blue, and indocyanine green. 7. The method according to claim 1, wherein the vital dye is present in a physiologically compatible solution in a concentration between 0.01% and 3% by weight. 8. The method according to claim 7, wherein the physiologically compatible solution comprises salt between 0.8% and 1.0% by weight. 9. The method according to claim 8, wherein the salt is selected from the group consisting of sodium chloride, sodium phosphate, potassium chloride, calcium chloride, and magnesium chloride.

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