You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 22, 2024

Claims for Patent: 6,713,485


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 6,713,485
Title: Heterocyclic compounds
Abstract:The present invention relates to substituted heteroaromatic compounds, methods for their preparation, pharmaceutical compositions containing them and their use in medicine. Specifically, the invention relates to quinazoline derivatives useful in treating disorders mediated by protein tyrosine kinase activity, in particular erbB-2 and/or EGFR activity.
Inventor(s): Carter; Malcolm Clive (Ware, GB), Cockerill; George Stuart (Bedford, GB), Guntrip; Stephen Barry (Hertford, GB), Lackey; Karen Elizabeth (Hillsborough, NC), Smith; Kathryn Jane (Hertfordshire, GB)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Application Number:10/071,358
Patent Claims: 1. A compound of the formula: ##STR54##

and salts or solvates thereof.

2. A pharmaceutical formulation, comprising: the compound of claim 1 or a pharmaceutically acceptable salt or solvate thereof together with one or more pharmaceutically acceptable carriers, diluents, or excipients.

3. A method of treating a susceptible cancer in a human or animal subject mammal, comprising administering to said subject an effective amount of a compound as claimed in claim 1, wherein said cancer is breast cancer, gastric cancer or head and neck cancer.

4. A method as claimed in claim 3, wherein the susceptible cancer is breast cancer.

5. A method as claimed in claim 3, wherein the susceptible cancer is gastric cancer.

6. A method as claimed in claim 3, wherein the susceptible cancer is head and neck cancer.

7. A compound of the formula: ##STR55##

and salts or solvates thereof.

8. A pharmaceutical formulation, comprising: the compound of claim 7 or a pharmaceutically acceptable salt or solvate thereof together with one or more pharmaceutically acceptable carriers, diluents, or excipients.

9. A method of treating a susceptible cancer in a human or animal subject mammal, comprising administering to said subject an effective amount of a compound as claimed in claim 7, wherein said cancer is breast cancer, gastric cancer or head and neck cancer.

10. A method as claimed in claim 9, wherein the susceptible cancer is breast cancer.

11. A method as claimed in claim 9, wherein the susceptible cancer is gastric cancer.

12. A method as claimed in claim 9, wherein the susceptible cancer is head and neck cancer.

13. A compound of the formula: ##STR56##

and salts or solvates thereof.

14. A pharmaceutical formulation, comprising: the compound of claim 13 or a pharmaceutically acceptable salt or solvate thereof together with one or more pharmaceutically acceptable carriers, diluents, or excipients.

15. A method of treating a susceptible cancer in a human or animal subject mammal, comprising administering to said subject an effective amount of a compound as claimed in claim 13, wherein said cancer is breast cancer, gastric cancer or head and neck cancer.

16. A method as claimed in claim 15, wherein the susceptible cancer is breast cancer.

17. A method as claimed in claim 15, wherein the susceptible cancer is gastric cancer.

18. A method as claimed in claim 15, wherein the susceptible cancer is head and neck cancer.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.