Claims for Patent: 6,821,975

Summary for Patent: 6,821,975

Title:	Beta-carboline drug products
Abstract:	A compound of structural formula (I), and pharmaceutically acceptable salts and solvates thereof, wherein the compound is in free drug particulate form, is disclosed.
Inventor(s):	Anderson; Neil R. (West Lafayette, IN), Hartauer; Kerry J. (Carmel, IN), Kral; Martha A. (Indianapolis, IN), Stephenson; Gregory A. (Fishers, IN)
Assignee:	Lilly ICOS LLC (Wilmington, DE)
Application Number:	10/031,463
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,821,975
Patent Claims:	1. A free drug particulate form of a compound having a formula ##STR3## or pharmaceutically acceptable salts and solvates thereof, comprising particles of the compound wherein at least 90% of the particles have a particle size of less than about 40 microns. 2. The free drug particulate form of claim 1 wherein at least 90% of the particles have a particle size of less than about 25 microns. 3. The free drug particulate form of claim 1 wherein at least 90% of the particles have a particle size of less than about 15 microns. 4. The free drug particulate form of claim 1 wherein at least 90% of the particles have a particle size of less than about 10 microns. 5. A pharmaceutical solid composition comprising the free drug particulate form as in any one of claims 1-4 and one or more pharmaceutically-acceptable carriers, diluents, or excipients. 6. A method of treating sexual dysfunction in a patient in need thereof, which comprises administering to the patient a therapeutically effective amount of a solid composition comprising the free drug particulate form as in any one of claims 1-4 and one or more pharmaceutically-acceptable carriers, diluents, or excipients. 7. The method of claim 6 wherein the sexual dysfunction is male erectile dysfunction. 8. The method of claim 6 wherein the sexual dysfunction is female sexual arousal disorder. 9. A method of manufacturing the free drug particulate form of claim 1 comprising: (a) providing a solid, free form of the compound, and (b) comminuting the solid free form of the compound to provide particles of the compound wherein at least 90% of the particles have a particle size of less than about 40 microns. 10. The method of claim 9 further comprising the step of admixing the particles of step (b) with one or more pharmaceutically-acceptable carriers, diluents, or excipients. 11. A pharmaceutical solid composition prepared by admixing particles of a compound having a formula ##STR4## or a pharmaceutically acceptable salt or solvate thereof, with one or more pharmaceutically acceptable carrier, diluent, or excipient, wherein the particles of the compound have a d90=40 or less.