Claims for Patent: 6,849,253
✉ Email this page to a colleague
Summary for Patent: 6,849,253
Title: | Use of borate-polyol complexes in ophthalmic compositions |
Abstract: | Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol. |
Inventor(s): | Chowhan; Masood (Arlington, TX), Dassanayake; Nissanke L. (Arlington, TX) |
Assignee: | Alcon Manufacturing, Ltd. (Fort Worth, TX) |
Application Number: | 10/302,294 |
Patent Claims: |
1. An aqueous ophthalmic solution comprising: 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water;
wherein the borate-polyol complex comprises a borate compound selected from the group consisting of boric acid and pharmaceutically acceptable salts thereof and propylene glycol, and the molar ratio of borate to polyol is 1:0.1 to 1:10.
2. An aqueous ophthalmic solution according to claim 1, wherein the solution further comprises an effective amount of a viscosity-enhancing polymer. 3. An aqueous ophthalmic solution according to claim 2, wherein the viscosity-enhancing polymer comprises a cellulosic polymer. 4. An aqueous ophthalmic solution according to claim 3, wherein the cellulosic polymer comprises hydroxypropyl methylcellulose. 5. An aqueous ophthalmic solution according to claim 1, wherein the solution does not contain an ophthalmically acceptable antimicrobial agent. 6. An aqueous ophthalmic solution according to claim 1, wherein the solution contains the borate-polyol complex in an amount of 1.0 to 2.5 wt. %. 7. An aqueous ophthalmic solution according to claim 6, wherein the molar ratio of borate to polyol is 1:0.1 to 1:1. 8. An aqueous ophthalmic solution according to claim 6, wherein the molar ratio of borate to polyol is 1:0.25 to 1:2.5. 9. An aqueous ophthalmic solution according to claim 6, wherein the solution does not contain any ophthalmically acceptable antimicrobial agent. 10. An aqueous ophthalmic solution comprising: 0.5 to 6.0 wt. % of a water soluble borate-polyol complex to enhance the antimicrobial activity of the solution, and water; wherein the borate-polyol complex comprises a borate compound selected from the group consisting of boric acid and pharmaceutically salts thereof and sorbitol, and the molar ratio of borate to polyol is 1:0.1 to 1:10. 11. An aqueous ophthalmic solution according to claim 10, wherein the solution further comprises an effective amount of a viscosity-enhancing polymer. 12. An aqueous ophthalmic solution according to claim 11, wherein the viscosity-enhancing polymer comprises a cellulosic polymer. 13. An aqueous ophthalmic solution according to claim 12, wherein the cellulosic polymer comprises hydroxypropyl methylcellulose. 14. An aqueous ophthalmic solution according to claim 10, wherein the solution does not contain an ophthalmically acceptable antimicrobial agent. 15. An aqueous ophthalmic solution according to claim 10, wherein the solution contains the borate-polyol complex in an amount of 1.0 to 2.5 wt. %. 16. An aqueous ophthalmic solution according to claim 15, wherein the molar ratio of borate to polyol is 1:0.1 to 1:1. 17. An aqueous ophthalmic composition according to claim 15, wherein the molar ratio of borate to polyol is 1:0.25 to 1:2.5. 18. An aqueous ophthalmic solution according to claim 15, wherein the solution does not contain an ophthalmically acceptable antimicrobial agent. |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.