Claims for Patent: 7,265,099
✉ Email this page to a colleague
Summary for Patent: 7,265,099
Title: | Use of chemical chelators as reversal agents for drug-induced neuromuscular block |
Abstract: | The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) wherein R is (a), (b) or (c); or general formula (B) wherein X is (a), (b) or (d), or a pharmaceutically acceptable salt thereof. |
Inventor(s): | Bom; Antonius Helena Adolf (Midlothian, GB), Muir; Alan William (Lanark, GB), Rees; David (Gothenburg, SE) |
Assignee: | Organon N.V. (Oss, NL) |
Application Number: | 10/049,393 |
Patent Claims: |
1. A method for reversal of drug-induced neuromuscular block in a patient caused by a clinically-used neuromuscular blocking agent which acts by reversible binding to
the acetylcholine receptor, comprising parenterally administering to said patient an effective amount of .gamma.-cyclodextrin or a derivative thereof capable of forming a guest-host complex with the neuromuscular blocking agent inducing the neuromuscular
block in the patient, and which is selected from the group consisting of rocuronium, vecuronium, pancuronium, rapacuronium, mivacurium, (cis)atracurium and tubocurarine.
2. The method according to claim 1, wherein the neuromuscular blocking agent is rocuronium or vecuronium. 3. A method for reversal of drug-induced neuromuscular block in a patient caused by a clinically-used neuromuscular blocking agent which acts by reversible binding to the acetylcholine receptor, comprising parenterally administering to said patient an effective amount of .beta.-cyclodextrin or a derivative thereof capable of forming a guest-host complex with the neuromuscular blocking agent inducing the neuromuscular block in the patient, the neuromuscular blocking agent being rocuronium. |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.