Claims for Patent: 7,288,657

Summary for Patent: 7,288,657

Title:	Biphenyl compounds useful as muscarinic receptor antagonists
Abstract:	This invention provides compounds of formula I: ##STR00001## wherein a, b, c, d, m, n, p, s, t, W, Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Inventor(s):	Mammen; Mathai (Redwood Shores, CA), Ji; Yu-Hua (Redwood City, CA), Mu; YongQi (Los Altos, CA), Husfeld; Craig (Redwood City, CA), Li; Li (Sunnyvale, CA)
Assignee:	Theravance, Inc. (South San Francisco, CA)
Application Number:	11/077,433
Patent Claims:	1. A compound of formula I: ##STR00037## wherein: a is 0 or an integer of from 1 to 5; each R.sup.1 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, --OR.sup.1a, --C(O)OR.sup.1b, --SR.sup.1c, --S(O)R.sup.1d, --S(O).sub.2R.sup.1e, --NR.sup.1fR.sup.1g, --NR.sup.1hS(O).sub.2R.sup.1i, and --NR.sup.1jC(O)R.sup.1k; where each of R.sup.1a, R.sup.1b, R.sup.1c, R.sup.1d, R.sup.1e, R.sup.1f, R.sup.1g, R.sup.1h, R.sup.1i, R.sup.1j, and R.sup.1k is independently hydrogen, (1-4C)alkyl or phenyl(1-4C)alkyl; b is 0 or an integer of from 1 to 4; each R.sup.2 is independently selected from (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (3-6C)cycloalkyl, cyano, halo, --OR.sup.2a, --C(O)OR.sup.2b, --SR.sup.2c, --S(O)R.sup.2d, --S(O).sub.2R.sup.2e, --NR.sup.2fR.sup.2g, --NR.sup.2hS(O).sub.2R.sup.2i, and --NR.sup.2jC(O)R.sup.2k; where each of R.sup.2a, R.sup.2b, R.sup.2c, R.sup.2d, R.sup.2e, R.sup.2f, R.sup.2g, R.sup.2h, R.sup.2i, R.sup.2j, and R.sup.2k is independently hydrogen, (1-4C)alkyl or phenyl(1-4C)alkyl; W represents O or NW.sup.a, where W.sup.a is hydrogen or (1-4C)alkyl; c is 0 or an integer from 1 to 5; each R.sup.3 independently represents (1-4C)alkyl or two R.sup.3 groups are joined to form (1-3C)alkylene, (2-3C)alkenylene or oxiran-2,3-diyl; m is 0 or 1; R.sup.4 is selected from hydrogen, (1-4C)alkyl, and (3-4C)cycloalkyl; s is 0, 1 or 2; Ar.sup.1 represents a phenylene group or a (3-5C)heteroarylene group containing 1 or 2 heteroatoms independently selected from oxygen, nitrogen or sulfur; wherein the phenylene or heteroarylene group is substituted with (R.sup.5).sub.q where q is 0 or an integer from 1 to 4 and each R.sup.5 is independently selected from halo, hydroxy, (1-4C)alkyl or (1-4C)alkoxy; t is 0, 1 or 2; n is 0 or an integer from 1 to 3; d is 0 or an integer from 1 to 4; each R.sup.6 independently represents fluoro or (1-4C)alkyl; p is 0 or 1; and R.sup.7 and R.sup.8 are independently hydrogen or (1-4C)alkyl; wherein each alkyl and alkoxy group in R.sup.1, R.sup.1a-1k, R.sup.2, R.sup.2a-2k, R.sup.3, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is optionally substituted with 1 to 5 fluoro substituents; or a pharmaceutically acceptable salt or stereoisomer thereof. 2. The compound of claim 1, wherein a, b and c each represent 0. 3. The compound of claim 1, wherein W represents O. 4. The compound of claim 1, wherein m is 0, s is 0 and t is 1. 5. The compound of claim 1, wherein the --CONR.sup.7R.sup.8 group is in the para position, d is 0 and n is 2. 6. The compound of claim 1, wherein Ar.sup.1 represents phen-1,3-ylene, phen-1,4-ylene, 2,4-thienylene or 2,5-thienylene; wherein the phenylene or thienylene group is optionally substituted with one or two R.sup.5 substituents. 7. The compound of claim 6, wherein Ar.sup.1 represents phen-1,4-ylene or 2,4-thienylene, optionally substituted with one or two R.sup.5 substituents. 8. The compound of any one of claims 1 to 6, wherein R.sup.4 is selected from hydrogen, methyl and ethyl. 9. The compound of any one of claims 1 to 6, wherein R.sup.7 is selected from hydrogen, methyl, ethyl, n-propyl and isopropyl; and R.sup.8 is hydrogen. 10. The compound of any one of claims 1 to 6, wherein R.sup.7 and R.sup.8 are ethyl. 11. The compound of claim 1 wherein a, b and c each represent 0; W represents O; m is 0; s is 0; t is 1; Ar.sup.1 represents phen-1,4-ylene optionally substituted with one or two R.sup.5 substituents; d is 0; n is 2, the --CONR.sup.7R.sup.8 group is in the para position; and R.sup.8 is hydrogen. 12. The compound of claim 11, wherein R.sup.5 is independently selected from halo, (1-4C)alkyl or (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents. 13. A compound selected from: biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piper- idin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]ethylamino}ethyl)piperi- din-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{methyl-[4-(4-methylcarbamoylpiperidin-1-ylmethyl)benzoyl]amino}ethy- l)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-ethylcarbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)- piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{methyl-[4-(4-propylcarbamoylpiperidin-1-ylmethyl)benzoyl]amino}ethy- l)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-isopropylcarbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}et- hyl)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-{2-[4-(4-carbamoylpiperidin-1-ylmethyl)-2-fluorobenzoylamino]ethyl}pipe- ridin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[2,5-dibromo-4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino- }ethyl)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)-2-fluorobenzoyl]methylamino}et- hyl)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-{2-[4-(4-diethylcarbamoylpiperidin-1-ylmethyl)-2-fluorobenzoylamino]eth- yl}piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-diethylcarbamoylpiperidin-1-ylmethyl)-2-fluorobenzoyl]methyla- mino}ethyl)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-diethylcarbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethy- l)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(3-(S)-diethylcarbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}- ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[4-(2-carbamoyl-piperidin-1-ylmethyl)benzoyl]methylamino}ethyl)pipe- ridin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[4-(4-carbamoyl-piperidin-1-ylmethyl)-2-methoxybenzoyl]methylamino}- ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-(4-carbamoylpiperidin-1-ylmethyl)thiophene-2-carbonyl]methylamin- o}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-((R)-3-diethylcarbamoylpiperidin-1-ylmethyl)thiophene-2-carbonyl- ]methylamino}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-((R)-3-diethylcarbamoylpiperidin-1-ylmethyl)thiophene-2-carbonyl- ]amino}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-(4-carbamoylpiperidin-1-ylmethyl)thiophene-2-carbonyl]amino}ethy- l)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-((R)-3-diethylcarbamoylpiperidin-1-ylmethyl)-1H-pyrrole-2-carbon- yl]methylamino}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-(4-carbamoylpiperidin-1-ylmethyl)-1H-pyrrole-2-carbonyl]methylam- ino}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-((R)-3-diethylcarbamoylpiperidin-1-ylmethyl)furan-2-carbonyl]met- hylamino}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-(4-diethylcarbamoyl-piperidin-1-ylmethyl)furan-2-carbonyl]methyl- amino}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-(4-carbamoylpiperidin-1-ylmethyl)furan-2-carbonyl]-amino}ethyl)p- iperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{[5-((R)-3-diethylcarbamoylpiperidin-1-ylmethyl)furan-2-carbonyl]ami- no}ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-[2-({3-[4-(3-carbamoylpiperidin-1-ylmethyl)phenyl]propionyl}methylamino- )ethyl]piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-[2-({3-[4-(4-carbamoylpiperidin-1-ylmethyl)phenyl]propionyl}methylamino- )ethyl]piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{3-[4-(4-carbamoylpiperidin-1-ylmethyl)phenyl]propionylamino}ethyl)p- iperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{3-[4-(4-diethylcarbamoylpiperidin-1-ylmethyl)phenyl]propionylamino}- ethyl)piperidin-4-yl ester; biphenyl-2-yl-carbamic acid 1-(2-{3-[4-(3-diethylcarbamoylpiperidin-1-ylmethyl)phenyl]propionylamino}- ethyl)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-{2-[4-(4-carbamoylpiperidin-1-ylmethyl)benzoylamino]ethyl}piperidin-4-y- l ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)-2-chloro-benzoyl]methylamino}e- thyl)piperidin-4-yl ester; biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)-2-chloro-5-methoxybenzoyl]meth- ylamino}ethyl)piperidin-4-yl ester; and biphenyl-2-ylcarbamic acid 1-[2-({2-[4-(4-carbamoylpiperidin-1-ylmethyl)phenyl]acetyl}methylamino)et- hyl]piperidin-4-yl ester; or a pharmaceutically acceptable salt or solvate thereof. 14. Biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piper- idin-4-yl ester or a pharmaceutically acceptable salt thereof. 15. A process for preparing a compound of any one of claims 1, 13 or 14, the process comprising: (a) reacting a compound of formula II: ##STR00038## or a salt thereof, with a compound of formula III: ##STR00039## wherein Z.sup.1 represents a leaving group; or (b) coupling a compound of formula IV: ##STR00040## with a compound of formula V: ##STR00041## or; (c) reacting a compound of formula VI: ##STR00042## wherein Z.sup.2 represents a leaving group; with a compound of formula VII: ##STR00043## or (d) reacting a compound of formula II with a compound of formula VIII: ##STR00044## in the presence of a reducing agent; or (e) reacting a compound of formula IX: ##STR00045## with a compound of formula VII in the presence of a reducing agent; or (f) reacting a compound of formula XVIII: ##STR00046## where R' is H, --CH.sub.3 or --CH.sub.2CH.sub.3, with a compound of formula XIX: NHR.sup.7R.sup.8 XIX to provide a compound of formula I. 16. The process of claim 15, which further comprises forming a pharmaceutically acceptable salt of the compound of formula I. 17. The product prepared by the process of claim 15. 18. The product prepared by the process of claim 16.