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Last Updated: December 27, 2024

Claims for Patent: 7,399,865

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Summary for Patent: 7,399,865

Title:	Protein tyrosine kinase enzyme inhibitors
Abstract:	This invention provides compounds of formula 1, having the structure ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are described within the specification.
Inventor(s):	Wissner; Allan (Ardsley, NY), Rabindran; Sridhar Krishna (Chestnut Ridge, NY), Tsou; Hwei-Ru (New City, NY)
Assignee:	Wyeth (Madison, NJ)
Application Number:	10/939,007
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 7,399,865
Patent Claims:	1. A compound: (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4- -(dimethylamino)-2-butenamide or a pharmaceutically acceptable salt thereof. 2. A compound: (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quin- olinyl}-4-(dimethylamino)-2-butenamide or a pharmaceutically acceptable salt thereof. 3. A compound: (E)-N-(4-{3-chloro-4-[(3-fluorobenzyl )oxy]anilino}-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenami- de or a pharmaceutically acceptable salt thereof. 4. A compound: (2E)-N-(4-{[3-chloro-4-(1,3-thiazol-2-ylsulfanyl)phenyl]amino}-3-cyano-7-- methoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide or A compound: (E)-N-(4-{3-chloro-4-[(4,6-di-methyl-2-pyrimidinyl)sulfanyl]anilino}-3-cy- ano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide or a pharmaceutically acceptable salt thereof. 5. A compound (E)-N-{4-[3-chloro -4-(1,3-thiazol-2-ylsulfanyl )anilino]-3-cyano-7-methoxy-6-quinolinyl}-4-[(2-methoxyethyl)(methyl)amin- o]-2-butenamide or a pharmaceutically acceptable salt thereof. 6. A pharmaceutical composition comprising: (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4- -(dimethylamino)-2-butenamide or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 7. A pharmaceutical composition comprising: (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quin- olinyl}-4-(dimethylamino)-2-butenamide or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 8. A pharmaceutical composition comprising: (E) -N-(4-{3-chloro-4-[(3-fluorobenzyl)oxy]anilino}-3-cyano-7-ethoxy-6-quinol- inyl)-4-(dimethylamino)-2-butenamide or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 9. A pharmaceutical composition comprising: (E)-N-(4-{3-chloro-4-[(4-methyl-2-pyrimidinyl)sulfanyl]anilino}-3-cyano -7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 10. A pharmaceutical composition comprising (E)-N-{4-[3-chloro-4-(1,3-thiazol-2-ylsulfanyl )anilino]-3-cyano-7-methoxy-6-quinolinyl}-4-[(2-methoxyethyl)(methyl)amin- o]-2-butenamide or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

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