Claims for Patent: 7,488,827

Summary for Patent: 7,488,827

Title:	Muscarinic acetylcholine receptor antagonists
Abstract:	Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
Inventor(s):	Laine; Damane I. (King of Prussia, PA), Palovich; Michael R. (King of Prussia, PA), McCleland; Brent W. (King of Prussia, PA), Neipp; Christopher E. (King of Prussia, PA), Thomas; Sonia M. (King of Prussia, PA)
Assignee:	Glaxo Group Limited (Greenford, Middlesex, GB)
Application Number:	11/774,867
Patent Claims:	1. The compound which is 4-[hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicycl- o[2.2.2]octane bromide. 2. A pharmaceutical composition comprising 4-[hydroxy(diphenyl)methyl]-1-{2-[(phenylmethyl)oxy]ethyl}-1-azoniabicycl- o[2.2.2]octane bromide and a pharmaceutically acceptable carrier thereof. 3. The compound ##STR00047## wherein X is a pharmaceutically acceptable anion. 4. The compound according to claim 3 wherein the pharmaceutically acceptable anion is chloride, bromide, iodide, hydroxide, sulfate, nitrate, phosphate, acetate, trifluoroacetate, fumarate, citrate, tartrate, oxalate, succinate, mandelate, methanesulfonate or p-toluenesulfonate. 5. The compound according to claim 3 wherein the pharmaceutically acceptable anion is bromide. 6. The compound according to claim 3 wherein the pharmaceutically acceptable anion is iodide. 7. A pharmaceutical composition comprising the compound ##STR00048## wherein X is a pharmaceutically acceptable anion, and a pharmaceutically acceptable carrier thereof. 8. The composition according to claim 7 wherein the pharmaceutically acceptable anion is chloride, bromide, iodide, hydroxide, sulfate, nitrate, phosphate, acetate, trifluoroacetate, fumarate, citrate, tartrate, oxalate, succinate, mandelate, methanesulfonate or p-toluenesulfonate. 9. The composition according to claim 7 wherein the pharmaceutically acceptable anion is bromide. 10. The composition according to claim 7 wherein the pharmaceutically acceptable anion is iodide. 11. A pharmaceutical composition according to claim 2 in a form suitable for administration by oral or nasal inhalation. 12. A pharmaceutical composition according to claim 11 wherein the form is suitable for administration by inhalation via a medicament dispenser selected from a reservoir dry powder inhaler, multi-dose dry powder inhaler, or a metered dose inhaler. 13. A pharmaceutical composition according to claim 2 which is a dry powder composition. 14. A pharmaceutical composition according to claim 2 wherein the pharmaceutically acceptable carrier is lactose. 15. A pharmaceutical composition according to claim 7 in a form suitable for administration by oral or nasal inhalation. 16. A pharmaceutical composition according to claim 15 wherein the form is suitable for administration by inhalation via a medicament dispenser selected from a reservoir dry powder inhaler, a multi-dose dry powder inhaler, or a metered dose inhaler. 17. A pharmaceutical composition according to claim 7 which is a dry powder composition. 18. A pharmaceutical composition according to claim 7 wherein the pharmaceutically acceptable carrier is lactose.