Claims for Patent: 7,544,192
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Summary for Patent: 7,544,192
Title: | Sinus delivery of sustained release therapeutics |
Abstract: | The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers. |
Inventor(s): | Eaton; Donald J. (Woodside, CA), Moran; Mary L. (Woodside, CA), Brenneman; Rodney (San Juan Capistrano, CA) |
Assignee: | Sinexus, Inc. (Palo Alto, CA) |
Application Number: | 10/800,162 |
Patent Claims: |
1. A method for delivering a biodegradable implant into a paranasal sinus cavity comprising: a) loading one or more biodegradable implants into a conduit having a
lumen, a distal portion, a side wall, a tip, and an opening in the distal portion; b) creating access to the paranasal sinus cavity with the loaded conduit; and c) delivering the one or more biodegradable implants through the opening in the distal
portion of the conduit into the paranasal sinus cavity, wherein the one or more biodegradable implants comprise a therapeutic amount of an active agent for the treatment of sinusitis.
2. The method of claim 1 wherein creating access comprises advancing the conduit through a paranasal sinus ostium. 3. The method of claim 1 wherein creating access comprises advancing the conduit through a paranasal sinus wall. 4. The method of claim 1 wherein delivering the one or more biodegradable implants comprises delivering the one or more biodegradable implants with a pusher. 5. The method of claim 1 wherein delivering the one or more biodegradable implants comprises contacting the one or more biodegradable implants with a pressurized gas. 6. The method of claim 1 wherein the distal portion of the conduit is angulated. 7. The method of claim 1 wherein the conduit is sharp-tipped. 8. The method of claim 1 wherein the distal opening is located in the side wall of the conduit. 9. The method of claim 1 wherein the distal opening is located at the tip of the conduit. 10. The method of claim 1 wherein the biodegradable implant is a biodegradable polymeric implant. 11. A method for delivering a biodegradable implant into a paranasal sinus cavity comprising: a) loading one or more biodegradable implants into a conduit having a lumen, a distal portion, a side wall, a tip, and an opening in the distal portion; b) creating access to the paranasal sinus cavity with the loaded conduit; and c) delivering the one or more biodegradable implants through the opening in the distal portion of the conduit into the paranasal sinus cavity, wherein the one or more biodegradable implants comprise a therapeutic amount of an active agent for the reduction of inflammation. 12. The method of claim 11 wherein creating access comprises advancing the conduit through a paranasal sinus ostium. 13. The method of claim 11 wherein creating access comprises advancing the conduit through a sinus wall. 14. The method of claim 11 wherein the biodegradable implant is a biodegradable polymeric implant. 15. The implant of claim 11 wherein the active agent comprises mometasone furoate. |
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