Claims for Patent: 7,544,364

Summary for Patent: 7,544,364

Title:	Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
Abstract:	Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical compositions.
Inventor(s):	Judice; J. Kevin (El Granada, CA), Shaw; Jeng-Pyng (Saratoga, CA), Mu; YongQi (Los Altos, CA), Conner; Michael W. (Half Moon Bay, CA), Pace; John L. (San Anselmo, CA)
Assignee:	Theravance, Inc. (South San Francisco, CA)
Application Number:	11/410,597
Patent Claims:	1. A pharmaceutical composition comprising: (a) a cyclodextrin; and (b) a glycopeptide antibiotic or a pharmaceutically acceptable salt thereof; wherein the glycopeptide antibiotic has the formula: ##STR00008## Wherein R.sup.20 is a lipid substituent containing from 10 to 40 carbon atoms, and optionally containing heteroatoms selected from halo, oxygen, nitrogen, sulfur and phosphorous; and wherein R.sup.19 is hydrogen, and R.sup.5 is a substituent of the formula: --CH.sub.2--NH--R.sup.a--P(O)(OH).sub.2 wherein R.sup.a is alkylene. 2. The pharmaceutical composition of claim 1, wherein the cyclodextrin is hydroxypropyl-.beta.-cyclodextrin. 3. The pharmaceutical composition of claim 1, wherein the cyclodextrin is sulfobutyl ether .beta.-cyclodextrin. 4. The pharmaceutical composition of claim 1, wherein the composition is a lyophilized powder. 5. The pharmaceutical composition of claim 1, wherein the cyclodextrin comprises about 1 to 40 weight percent of the composition. 6. The pharmaceutical composition of claim 1, wherein the glycopeptide antibiotic is in the form of a pharmaceutically acceptable salt. 7. The pharmaceutical composition of claim 1, wherein the glycopeptide antibiotic is in the form of a hydrochloride salt.