Claims for Patent: 7,553,828

Summary for Patent: 7,553,828

Title:	9-aminomethyl substituted minocycline compounds
Abstract:	The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
Inventor(s):	Nelson; Mark L. (Norfolk, MA), Frechette; Roger (Reading, MA), Ismail; Mohamed Y. (Bedford, MA), Honeyman; Laura (Roslindale, MA), Bowser; Todd (Charlton, MA), Bhatia; Beena (Arlington, MA)
Assignee:	Paratek Pharmaceuticals, Inc. (Boston, MA)
Application Number:	10/786,881
Patent Claims:	1. A compound of the formula: ##STR00045## or a pharmaceutically acceptable salt or ester thereof. 2. A compound of the formula: ##STR00046## or a pharmaceutically acceptable salt thereof. 3. A compound of the formula: ##STR00047## 4. A pharmaceutical composition comprising a therapeutically effective amount of a compound of any one of claims 1, 2 and 3, and a pharmaceutically acceptable carrier.