Claims for Patent: 7,585,879
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Summary for Patent: 7,585,879
| Title: | Biphenyl compounds useful as muscarinic receptor antagonists |
| Abstract: | This invention provides compounds of formula I: ##STR00001## wherein a, b, c, d, m, n, p, s, t, W, Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders. |
| Inventor(s): | Mammen; Mathai (Redwood Shores, CA), Ji; Yu-Hua (Redwood City, CA), Mu; YongQi (Los Altos, CA), Husfeld; Craig (Redwood City, CA), Li; Li (Sunnyvale, CA) |
| Assignee: | Theravance, Inc. (South San Francisco, CA) |
| Application Number: | 11/879,996 |
| Patent Claims: |
1. A compound of formula: ##STR00037##
2. A pharmaceutically acceptable salt of a compound of formula: ##STR00038## 3. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the compound of claim 1. 4. The pharmaceutical composition of claim 3, wherein the composition further comprises a therapeutically effective amount of an agent selected from .beta..sub.2 adrenergic receptor agonists, steroidal anti-inflammatory agents, phosphodiesterase-4 inhibitors, and combinations thereof. 5. The pharmaceutical composition of claim 4, wherein the composition comprises a therapeutically effective amount of a .beta..sub.2 adrenergic receptor agonist and a steroidal anti-inflammatory agent. 6. A method of producing bronchodilation in a patient, the method comprising administering to a patient a bronchodilation-producing amount of the compound of claim 1. 7. A method of treating chronic obstructive pulmonary disease or asthma, the method comprising administering to a patient a therapeutically effective amount of the compound of claim 1. 8. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the compound of claim 2. 9. The pharmaceutical composition of claim 8, wherein the composition further comprises a therapeutically effective amount of an agent selected from .beta..sub.2 adrenergic receptor agonists, steroidal anti-inflammatory agents, phosphodiesterase-4 inhibitors, and combinations thereof. 10. The pharmaceutical composition of claim 9, wherein the composition comprises a therapeutically effective amount of a .beta..sub.2adrenergic receptor agonist and a steroidal anti-inflammatory agent. 11. A method of producing bronchodilation in a patient, the method comprising administering to a patient a bronchodilation-producing amount of the compound of claim 2. 12. A method of treating chronic obstructive pulmonary disease or asthma, the method comprising administering to a patient a therapeutically effective amount of the compound of claim 2. |
