Claims for Patent: 7,598,276

Summary for Patent: 7,598,276

Title:	Pharmaceutical salts and polymorphs of a factor Xa inhibitor
Abstract:	The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I. ##STR00001##
Inventor(s):	Grant; Craig (Burwell, GB), Kanter; James P. (San Ramon, CA), Langlands; Graeme (Soham, GB)
Assignee:	Millenium Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:	11/594,280
Patent Claims:	1. A salt represented by Formula II: ##STR00014## having a crystalline polymorph form. 2. The salt of claim 1, having a powder X-ray diffraction pattern having at least four approximate characteristic peak locations selected from 4.9, 9.7, 13.8, 14.1, 15.2, 17.6, 18.5, 20.8, 21.6, 22.7, 24.1, 26.3, 26.8 degrees 2.theta.. 3. The salt of claim 1, having a powder X-ray diffraction pattern having at least eight approximate characteristic peak locations selected from 4.9, 9.7, 11.8, 13.8, 14.1, 15.2, 17.6, 18.5, 19.9, 20.8, 21.6, 22.7, 24.1, 25.0, 26.3, 26.8 degrees 2.theta.. 4. The salt of claim 1, having a powder X-ray diffraction pattern approximate to the powder X-ray diffraction pattern shown in FIG. 1. 5. The salt of claim 1, having a differential scanning calorimetry approximate to the differential scanning calorimetry pattern shown in FIG. 2.