Claims for Patent: 7,838,042

Summary for Patent: 7,838,042

Title:	Hypoallergenic metal amino acid chelates and metal amino acid chelate-containing compositions
Abstract:	Hypoallergenic metal amino acid chelate compositions, hypoallergenic formulations containing hypoallergenic metal amino acid chelates, methods of preparing hypoallergenic metal amino acid chelate, and methods of administering hypoallergenic metal amino acid chelates are provided. Specifically, the present invention provides metal amino acid chelates that are substantially free of allergens such that administration of the metal amino acid chelates to a subject in an effective amount to cause a medicinal or nutritional result does not produce a discernable adverse allergic reaction. The metal amino acid chelates can include chelates having a naturally occurring amino acid to metal molar ratio of from about 1:1 to 4:1.
Inventor(s):	Motyka; Max R. (St. Clair Shores, MI), Harnish; Rick (Miami, FL), Ashmead; Stephen D. (Clinton, UT), Ashmead; H. DeWayne (Fruit Heights, UT)
Assignee:	Albion International, Inc. (Clearfield, UT)
Application Number:	10/828,827
Patent Claims:	1. A method of preparing a hypoallergenic metal amino acid chelate composition, comprising: a) selecting an amino acid source determined to be hypoallergenic; b) selecting a metal source determined to be hypoallergenic; and c) chelating an amino acid of the amino acid source to a metal of the metal source to form a hypoallergenic metal amino acid chelate composition wherein the hypoallergenic metal amino acid chelate composition includes coordinate covalent bonding and has an amino acid to metal ratio from about 1:1 to 3:1. 2. A method as in claim 1, wherein during the step of selecting the amino acid source, if a first amino acid source is not hypoallergenic, additional amino acid sources are evaluated until a hypoallergenic amino acid source is ascertained. 3. A method as in claim 1, wherein during the step of selecting the metal source, if a first metal source is not hypoallergenic, additional metal sources are evaluated until a hypoallergenic metal source is ascertained. 4. A method as in claim 1, wherein the amino acid source is rendered hypoallergenic after formation, but before chelation with the metal. 5. A method as in claim 1, further comprising selecting an additive determined to be hypoallergenic, and including the additive as a mixture with the hypoallergenic metal amino acid chelate. 6. A method as in claim 5, wherein the additive is selected from the group consisting of hypoallergenic organic acids, hypoallergenic free amino acids, hypoallergenic amino acid salts, hypoallergenic fillers, hypoallergenic flow control agents, hypoallergenic lubricants, hypoallergenic flow agents, hypoallergenic hydroscopicity reducing agents, hypoallergenic pH control agents, hypoallergenic catalysts, hypoallergenic vitamins, hypoallergenic dust control agents, hypoallergenic binders, hypoallergenic disintegrating agents, hypoallergenic flavoring agents, hypoallergenic flavoring agents, hypoallergenic taste-reducing agents, hypoallergenic capsule shells, hypoallergenic shellacs, hypoallergenic waxes, hypoallergenic gelatin sources, hypoallergenic emulsifiers, hypoallergenic oils, and combinations thereof 7. A method as in claim 5, wherein the additive is a hypoallergenic organic acid selected from the group consisting of citric acid, furnaric acid, succinic acid, tartaric acid, malic acid, lactic acid, gluconie acid, ascorbic acid, pantothenic acid, folic acid, lipoic acid, oxalic acid, maleic acid, formic acid, acetic acid, pyruvic acid, adipic acid, alpha-ketoglutaric acid, and mixtures thereof. 8. A method as in claim 5, wherein the additive is a hypoallergenic filler selected from the group consisting of grain flours, maltodextrins, vegetable flours or powders, inulin, and combinations thereof. 9. A method as in claim 5, wherein the additive is a hypoallergenic flow control agent selected from the group consisting of fumed silica, steuric acid, talc, and combinations thereof. 10. A method as in claim 5, wherein the additive is selected from the group consisting of hypoallergenic free amino acids, hypoallergenic amino acid salts, and combinations thereof. 11. A method as in claim 5, wherein the additive is selected from the group consisting of vitamins, coenzymes, cofactors, herbs, herbal extracts, protein powders, and combinations thereof. 12. A method as in claim 5, wherein the additive is selected from the group consisting of mineral oils, binders, flavoring or taste-free additives, and combinations thereof. 13. A method as in claim 1, wherein the naturally occurring amino acid is selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and combinations thereof. 14. A method as in claim 1, wherein the metal is selected from the group consisting of iron, zinc, copper, manganese, calcium, chromium, vanadium, selenium, silicon, molybdenum, tin, nickel, boron, cobalt, gold, silver, and combinations thereof. 15. A method as in claim 1, wherein the metal is ferrous iron and the naturally occurring amino acid is glycine, and wherein the glycine to iron molar ratio is about 2:1. 16. A method as in claim 1, wherein the metal is copper and the naturally occurring amino acid is glycine, and wherein the glycine to copper molar ratio is about 2:1. 17. A method as in claim 1, wherein the metal is zinc and the naturally occurring amino acid is glycine, and wherein the glycine to zinc molar ratio is about 2:1. 18. A method as in claim 1, wherein the metal is manganese and the naturally occurring amino acid is glycine, and wherein the glycine to manganese molar ratio is about 2:1. 19. A method as in claim 1, wherein the metal is ferric iron and the naturally occurring amino acid is glycine, and wherein the glycine to ferric iron molar ratio is about 3:1. 20. A method as in claim 1, wherein the metal is chromium and the naturally occurring amino acid is glycine, and wherein the glycine to chromium molar ratio is about 3:1. 21. A method as in claim 1, wherein the metal is magnesium and the naturally occurring amino acid is glycine, and wherein the magnesium to glycine molar ratio is about 1:1. 22. A method as in claim 1, wherein the metal is calcium and the naturally occurring amino acid is glycine, and wherein the calcium to glycine molar ratio is about 1:1. 23. A method as in claim 22, wherein the allergens are removed from the naturally occurring amino acid after formation, but before chelation with the metal. 24. A method as in claim 22, wherein the subject is human. 25. A method as in claim 1, wherein the hypoallergenic metal amino acid chelate composition is substantially free of allergens such that upon administration of the composition to a subject in an effective Mount to cause a medicinal or nutritional result, the composition does not produce a discernable adverse allergic reaction in the subject. 26. A method as in claim 1, wherein the amino acid source is prepared by synthetic synthesis. 27. A method as in claim 1, wherein the amino acid source is prepared by fermentation. 28. A method of administering a metal amino acid chelate composition, comprising: a) identifying a subject susceptible to a type of allergic reaction; b) formulating a metal amino acid chelate by: i) selecting an amino acid source determined to be hypoallergenic with respect to the type of allergic reaction; ii) selecting a metal source determined to be hypoallergenic with respect to the type of allergic reaction, and iii) chelating an amino acid of the amino acid source to a metal of the metal source to form a hypoallergenic metal amino acid chelate composition; and c) administering the hypoallergenic metal amino acid composition to the subject wherein the hypoallergenic metal amino acid chelate composition includes coordinate covalent bonding and has an amino acid to metal ratio from about 1:1 to 3:1. 29. A method as in claim 28, wherein the subject is allergic to at least one of soy, peanuts, tree nuts, crustaceans, finfish, dairy, wheat, eggs, corn, gelatin, whey, chocolate, and strawberries. 30. A method as in claim 28, wherein during the step of selecting the amino acid source, if a first amino acid source is not hypoallergenic, additional amino acid sources are evaluated until a hypoallergenic amino acid source is ascertained. 31. A method as in claim 30, wherein during the step of selecting the metal source, if a first metal source is not hypoallergenic, additional metal sources are evaluated until a hypoallergenic metal source is ascertained. 32. A method as in claim 28, wherein the amino acid source is rendered hypoallergenic after formation, but before chelation with the metal. 33. A method as in claim 28, further comprising steps of selecting an additive determined to be hypoallergenic, and including the additive as a mixture with the hypoallergenic metal amino acid chelate. 34. A method as in claim 33, wherein the additive is selected from the group consisting of hypoallergenic organic acids, hypoallergenic free amino acids, hypoallergenic amino acid salts, hypoallergenic fillers, hypoallergenic flow control agents, hypoallergenic lubricants, hypoallergenic flow agents, hypoallergenic hydroscopicity reducing agents, hypoallergenic pH control agents, hypoallergenic catalysts, hypoallergenic vitamins, hypoallergenic dust control agents, hypoallergenic binders, hypoallergenic disintegrating agents, hypoallergenic flavoring agents, hypoallergenic flavoring agents, hypoallergenic taste-reducing agents, hypoallergenic capsule shells, hypoallergenic shellacs, hypoallergenic waxes, hypoallergenic gelatin sources, hypoallergenic emulsifiers, hypoallergenic oils, and combinations thereof. 35. A method as in claim 33, wherein the additive is an hypoallergenic organic acid selected from the group consisting of citric acid, fumaric acid, succinic acid, tartaric acid, malic acid, lactic acid, gluconic acid, ascorbic acid, pantothenic acid, folic acid, lipoic acid, oxalic acid, maleic acid, formic acid, acetic acid, pyruvic acid, adipic acid, alplia-ketoglutaric acid, and mixtures thereof. 36. A method as in claim 33, wherein the additive is a hypoallergenic filler selected from the group consisting of grain flours, maltodextrins, vegetable flours or powders, inulin, and combinations thereof. 37. A method as in claim 33, wherein the additive is a hypoallergenic flow control agent selected from the group consisting of filmed silica, stearic acid, talc, and combinations thereof. 38. A method as in claim 33, wherein the additive is selected from the group consisting of hypoallergenic free amino acids, hypoallergenic amino acid salts, and combinations thereof. 39. A method as in claim 33, wherein the additive is selected from the group consisting of vitamins, coenzymes, cofactors, herbs, herbal extracts, protein powders, and combinations thereof. 40. A method as in claim 33, wherein the additive is selected from the group consisting of mineral oils, binders, flavoring or taste-free additives, and combinations thereof. 41. A method as in claim 28, wherein the naturally occurring amino acid is selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, praline, serine, threonine, tryptophan, tyrosine, valine, and combinations thereof. 42. A method as in claim 28, wherein the metal is selected from the group consisting of iron, zinc, copper, manganese, calcium, chromium, vanadium, selenium, silicon, molybdenum, tin, nickel, boron, cobalt, gold, silver, and combinations thereof. 43. A method as in claim 28, wherein the metal is ferrous iron and the naturally occurring amino acid is glycine, and wherein the glycine to iron molar ratio is about 2:1. 44. A method as in claim 28, wherein the metal is copper and the naturally occurring amino acid is glycine, and wherein the glycine to copper molar ratio is about 2:1. 45. A method as in claim 28, wherein the metal is zinc and the naturally occurring amino acid is glycine, and wherein the glycine to zinc molar ratio is about 2:1. 46. A method as in claim 28, wherein the metal is manganese and the naturally occurring amino acid is glycine, and wherein the glycine to manganese molar ratio is about 2:1. 47. A method as in claim 28, wherein the metal is ferric iron and the naturally occurring amino acid is glycine, and wherein the glycine to ferric iron molar ratio is about 3:1. 48. A method as in claim 28, wherein the metal is chromium and the naturally occurring amino acid is glycine, and wherein the glycine to chromium molar ratio is about 3:1. 49. A method us in claim 28, wherein the metal is magnesium and the naturally occurring amino acid is glycine, and wherein the magnesium to glycine molar ratio is about 1:1. 50. A method as in claim 28, wherein the metal is calcium and the naturally occurring amino acid is glycine, and wherein the calcium to glycine molar ratio is about 1:1. 51. A method as in claim 28, wherein the hypoallergenic metal amino acid chelate composition is substantially free of allergens such that upon administration of the composition to the subject in an effective amount to cause a medicinal or nutritional result, the composition does not produce a discernable adverse allergic reaction in the subject. 52. A method as in claim 51, wherein the allergens are removed from the naturally occurring amino acid after formation, but before chelation with the metal. 53. A method as in claim 28, wherein the subject is human. 54. A method as in claim 28, wherein the amino acid source is prepared by synthetic synthesis. 55. A method as in claim 28, wherein the amino acid source is prepared by fermentation.