Claims for Patent: 7,910,608

Summary for Patent: 7,910,608

Title:	Biphenyl compounds useful as muscarinic receptor antagonists
Abstract:	This invention provides compounds of formula I: ##STR00001## wherein a, b, c, d, m, n, p, s, t, W, Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
Inventor(s):	Mammen; Mathai (Redwood Shores, CA), Ji; Yu-Hua (Redwood City, CA), Mu; YongQi (Los Altos, CA), Husfeld; Craig (Redwood City, CA), Li; Li (Sunnyvale, CA)
Assignee:	Theravance, Inc. (South San Francisco, CA)
Application Number:	11/879,835
Patent Claims:	1. A compound of formula Ib: ##STR00037## wherein R.sup.4 is hydrogen or (1-4C)alkyl; q is 0, 1 or 2; R.sup.5 is independently selected from halo, (1-4C)alkyl and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents; R.sup.7 is hydrogen or (1-4C)alkyl; or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of claim 1. 3. The pharmaceutical composition of claim 2, wherein the composition further comprises a therapeutically effective amount of an agent selected from .beta..sub.2 adrenergic receptor agonists, steroidal anti-inflammatory agents, phosphodiesterase-4 inhibitors, and combinations thereof. 4. The pharmaceutical composition of claim 3, wherein the composition comprises a therapeutically effective amount of a .beta..sub.2 adrenergic receptor agonist and a steroidal anti-inflammatory agent.