Claims for Patent: 7,994,185
✉ Email this page to a colleague
Summary for Patent: 7,994,185
| Title: | Benzene sulfonamide thiazole and oxazole compounds |
| Abstract: | The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents. |
| Inventor(s): | Rheault; Tara Renae (Durham, NC) |
| Assignee: | Glaxo Smith Kline LLC (Philadelphia, PA) |
| Application Number: | 12/434,963 |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 7,994,185 |
| Patent Claims: |
1. A compound of formula ##STR00609## or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising a compound of claim 1, together with one or more of pharmaceutically acceptable carriers, diluents or excipients. 3. A pharmaceutical composition as claimed in claim 2 in unit dosage form. 4. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 1. 5. The method of claim 4, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution. 6. A compound of formula ##STR00610## 7. A pharmaceutical composition, comprising a compound of claim 6, together with one or more of pharmaceutically acceptable carriers, diluents or excipients. 8. A pharmaceutical composition as claimed in claim 7 in unit dosage form. 9. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 6. 10. The method of claim 9, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution. 11. A pharmaceutically acceptable salt of the compound of formula ##STR00611## 12. A pharmaceutical composition, comprising a compound of claim 11, together with one or more of pharmaceutically acceptable carriers, diluents or excipients. 13. A pharmaceutical composition as claimed in claim 12 in unit dosage form. 14. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 11. 15. The method of claim 14, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution. 16. N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-y- l]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide mesylate. 17. A pharmaceutical composition, comprising a compound of claim 16, together with one or more of pharmaceutically acceptable carriers, diluents or excipients. 18. A pharmaceutical composition as claimed in claim 16 in unit dosage form. 19. A method of treatment of a human suffering from melanoma, which comprises administering to said subject an effective amount of a compound as claimed in claim 16. 20. The method of claim 19, wherein the melanoma is metastatic melanoma having a mutation encoding a V600E amino acid substitution. |
