Claims for Patent: 8,012,976

Summary for Patent: 8,012,976

Title:	Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
Abstract:	A compound having the structure set forth in Formula (I) and Formula (II): ##STR00001## wherein the substituents Y, Z, A, B, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
Inventor(s):	Wang; Bing (San Jose, CA), Chu; Daniel (Santa Clara, CA)
Assignee:	BioMarin Pharmaceutical Inc. (Novato, CA)
Application Number:	12/510,096
Patent Claims:	1. A compound of the formula: ##STR00039## or a pharmaceutically acceptable salt thereof. 2. 5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dih- ydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one. 3. A pharmaceutical composition comprising a compound of the formula: ##STR00040## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent, excipient or carrier. 4. (8R,9S)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)- -8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one or a pharmaceutically acceptable salt thereof. 5. (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)- -8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one or a pharmaceutically acceptable salt thereof.