Claims for Patent: 8,053,448
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Summary for Patent: 8,053,448
| Title: | Biphenyl compounds useful as muscarinic receptor antagonists |
| Abstract: | This invention provides methods of using compounds of formula Ib below to treat pulmonary disorders. ##STR00001## wherein: R.sup.4 is hydrogen or (1-4C)alkyl; q is 0, 1, or 2; R.sup.5 is independently selected from halo, (1-4C)alkyl, and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents; R.sup.7 is hydrogen or (1-4C)alkyl; or a pharmaceuticallly acceptable salt thereof. |
| Inventor(s): | Mammen; Mathai (Menlo Park, CA), Ji; YuHua (Redwood City, CA), Mu; YongQi (Los Altos, CA), Husfeld; Craig (Redwood City, CA), Li; Li (Sunnyvale, CA) |
| Assignee: | Theravance, Inc. (South San Francisco, CA) |
| Application Number: | 13/024,532 |
| Patent Claims: |
1. A method of producing bronchodilation in a patient, the method comprising administering to a patient a bronchodilation-producing amount of a compound of formula Ib:
##STR00037## wherein: R.sup.4 is hydrogen or (1-4C)alkyl; q is 0, 1 or 2; R.sup.5 is independently selected from halo, (1-4C)alkyl and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents;
R.sup.7 is hydrogen or (1-4C)alkyl; or a pharmaceutically acceptable salt thereof.
2. A method of treating chronic obstructive pulmonary disease or asthma, the method comprising administering to a patient a therapeutically effective amount of a compound of formula Ib: ##STR00038## wherein: R.sup.4 is hydrogen or (1-4C)alkyl; q is 0, 1 or 2; R.sup.5 is independently selected from halo, (1-4C)alkyl and (1-4C)alkoxy, wherein each alkyl and alkoxy group is optionally substituted with from 1 to 3 fluoro substituents; R.sup.7 is hydrogen or (1-4C)alkyl; or a pharmaceutically acceptable salt thereof. |
