Claims for Patent: 8,114,863

Summary for Patent: 8,114,863

Title:	Compounds comprising short aminoalcohol chains and metal complexes for medical imaging
Abstract:	The present invention relates to a compound of formula (II) chosen from (IIa) and (IIb) or of formula (VI) chosen from (VIa) and (VIb) of following general formulae:
Inventor(s):	Port Marc
Assignee:	Guerbet
Application Number:	US12083092
Patent Claims:	2. Compound according to of formula (IIa) claim 1 , wherein E represents an N atom and D and Frepresent CH.3. Compound according to of formula (IIa) claim 1 , wherein X claim 1 , Xand Xindependently represent —(CH)—CO—NR7R8 or —(CH)—NR7-CO—R8 claim 1 , in which n is between 1 and 3 claim 1 , R7 represents H or a methyl group and R8 represents a C-Chydroxyalkyl group.5. Compound according to claim 4 , wherein X claim 4 , Xand Xindependently represent —(CH)—CONR7R8 claim 4 , in which n is between 1 and 3 claim 4 , R7 represents H and R8 represents —CH—CHOH claim 4 , —CHOH—CHOH claim 4 , —CH—(CHOH) claim 4 , —CH—(CHOH)—CHOH claim 4 , with p=1 to 4 claim 4 , or —C—(CHOH).6. Multimer of a compound according to .7. Complex of a compound according to with M claim 1 , M representing an ion of a paramagnetic metal of atomic number 21-29 claim 1 , 42-44 or 58-70 or a radionuclide chosen from Tc claim 1 , Sn claim 1 , In claim 1 , Ru claim 1 , Ga claim 1 , Ga claim 1 , Zr claim 1 , Lu claim 1 , Sc claim 1 , Rh claim 1 , Re claim 1 , Cu claim 1 , Cu claim 1 , Cu claim 1 , Cu claim 1 , Y claim 1 , Gd claim 1 , Pr and Ho.8. Complex of a multimer according to with M claim 6 , M representing an ion of a paramagnetic metal of atomic number 21-29 claim 6 , 42-44 or 58-70 or a radionuclide chosen from Tc claim 6 , Sn claim 6 , In claim 6 , Ru claim 6 , Ga claim 6 , Ga claim 6 , Zr claim 6 , Lu claim 6 , Sc claim 6 , Rh claim 6 , Re claim 6 , Cu claim 6 , Cu claim 6 , Cu claim 6 , Cu claim 6 , Y claim 6 , Gd claim 6 , Pr and Ho.9. Complex according to or claim 6 , wherein the ion of a paramagnetic metal is chosen from Gd claim 6 , Mn and Fe.10. Complex according to or claim 6 , wherein it exhibits:{'sup': −1', '−1', '−1, 'a relaxivity in water of at least 10 mMsGd,'}an osmolality of between 800 and 1200 mOsm/kg, for a Gd concentration of 400 to 600 mM, anda substantially stable relaxivity between 20 and 300 MHz, or an increase in relaxivity beyond 20 MHz.13. Pharmaceutical composition comprising a compound according to or a multimer according to or a complex according to or claim 6 , a pharmaceutically acceptable vehicle and optionally formulation additives.14. Lipid pharmaceutical composition comprising a compound according or a multimer according to or a complex according to or claim 6 , bonded to a lipid nanoparticle.15. Diagnostic composition for magnetic resonance imaging claim 6 , comprising a compound according to or a multimer according to compound according to or a complex according to or .