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Last Updated: November 23, 2024

Claims for Patent: 8,153,149

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Summary for Patent: 8,153,149

Title:	Controlled delivery system
Abstract:	The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.
Inventor(s):	Verity; A. Neil (Sunnyvale, CA)
Assignee:	Durect Corporation (Cupertino, CA)
Application Number:	11/888,658
Patent Claims:	1. A pharmaceutical composition for providing sustained local anaesthesia after administration to a subject, said composition comprising: about 66% by weight sucrose acetate isobutyrate (SAIB) liquid carrier material relative to the total weight of the composition; about 12% by weight bupivacaine relative to the total weight of the composition; and about 22% by weight benzyl alcohol (BA) relative to the total weight of the composition, wherein the bupivacaine is released from the composition for a period of at least 24 hours after administration in an amount sufficient to provide sustained local anesthesia. 2. The composition of claim 1, wherein the bupivacaine is present in free base form. 3. The composition of claim 1, wherein said composition is suitable for topical, systemic, or parenteral administration. 4. The composition of claim 1, wherein said composition is suitable for administration via injection, pouring, spraying, dipping, aerosolizing, or via a coating applicator.

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