Claims for Patent: 8,153,689

Summary for Patent: 8,153,689

Title:	Pleuromutilin derivatives for the treatment of diseases mediated by microbes
Abstract:	Disclosed are pleuromutilin derivatives of formula (I) ##STR00001## and their use in the treatment of diseases mediated by microbes.
Inventor(s):	Mang; Rosemarie (Vienna, AT), Heilmayer; Werner (Zillingtal, AT), Badegruber; Rudolf (Vienna, AT), Strickmann; Dirk B. (Vienna, AT), Novak; Rodger (Vienna, AT), Ferencic; Mathias (Vienna, AT), Bulusu; Atchyuta Rama Chandra Murty (Perchtoldsdorf, AT)
Assignee:	Nabriva Therapeutics AG (Vienna, AT)
Application Number:	13/252,732
Patent Claims:	1. A composition comprising the compound 14-O-{[(1R, 2R, 4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin, wherein said compound has the structure of formula (I): ##STR00011## 2. The composition of claim 1 in the form of a pharmaceutically acceptable salt. 3. The composition of claim 2 wherein said salt is selected from the group consisting of a sodium salt, a potassium salt, a calcium salt, a magnesium salt, trimethylammonium salt, an isopropylamine salt, a diethylamine salt, an ethanolamine salt, a trimethylamine salt, a dicyclohexyl amine salt, a N-methyl-D-glucamine salt, a hydrogen fumaric acid salt, a fumaric acid salt, a tartaric acid salt, an ethane-1,2-disulphonic acid salt, a naphthalin-1,5-sulphonic acid salt, an acetic acid salt, a maleic acid salt, a succinic acid salt, a salicylic acid salt, an azelaic acid salt, a 2-[(2,6-dichlorophenyl)amino]benzene acetic acid salt, and a hydrochloric acid salt. 4. The composition of claim 1, further comprising at least one pharmaceutically acceptable excipient. 5. The composition of claim 2, further comprising at least one pharmaceutically acceptable excipient.