Claims for Patent: 8,168,663

Summary for Patent: 8,168,663

Title:	Pharmaceutically acceptable salt of 6-carboxy-2-(3,5 dichlorophenyl)-benzoxazole, and a pharmaceutical composition comprising the salt thereof
Abstract:	Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods are disclosed.
Inventor(s):	Kelly; Jeffery W. (La Jolla, CA), Powers; Evan T. (La Jolla, CA), Razavi; Hossein (Danbury, CT)
Assignee:	The Scripps Research Institute (La Jolla, CA)
Application Number:	12/481,527
Patent Claims:	1. A pharmaceutically acceptable salt of the compound 6-Carboxy-2-(3,5-dichlorophenyl)-benzoxazole. 2. The pharmaceutically acceptable salt of claim 1 that is an N-methyl-D-glucamine salt. 3. A pharmaceutical composition, comprising the pharmaceutically acceptable salt of claim 1 and a pharmaceutically acceptable carrier. 4. A pharmaceutical composition, comprising the pharmaceutically acceptable salt of claim 2 and a pharmaceutically acceptable carrier.