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Last Updated: December 23, 2024

Claims for Patent: 8,173,107

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Summary for Patent: 8,173,107

Title:	Delivery of antipsychotics through an inhalation route
Abstract:	The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.
Inventor(s):	Rabinowitz; Joshua D. (Princeton, NJ), Zaffaroni; Alejandro C. (Atherton, CA)
Assignee:	Alexza Pharmaceuticals, Inc. (Mountain View, CA)
Application Number:	12/413,339
Patent Claims:	1. An aerosol for delivery of loxapine by inhalation comprising condensation particles having an MMAD of 0.2 to 5 microns and a high particle concentration of the condensation particles. 2. The aerosol of claim 1, wherein the aerosol is at least 90% free of additional compounds. 3. The aerosol of claim 1, wherein the condensation particles have and MMAD of 1-3 microns. 4. The aerosol of claim 1, wherein the high particle concentration of the condensation particles is about 10.sup.9 particles/ml. 5. An aerosol for delivery of loxapine by inhalation comprising condensation particles having an MMAD of 0.2 to 5 microns and a particle density greater than 10.sup.6 particles/ml. 6. The aerosol of claim 5, wherein the aerosol is at least 90% free of additional compounds. 7. The aerosol of claim 5, wherein the condensation particles have an MMAD of 1-3 microns. 8. The aerosol of claim 5, wherein the aerosol has a particle density of about 10.sup.9 particles/ml.

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