Claims for Patent: 8,207,215

Summary for Patent: 8,207,215

Title:	Ketorolac tromethamine compositions for treating or preventing ocular pain
Abstract:	Compositions comprising ketorolac tromethamine at a therapeutically effective concentration of less than 0.5% are disclosed herein. Methods of treating or preventing ocular pain using said compositions are also disclosed herein.
Inventor(s):	Muller; Christopher A. (Foothill Ranch, CA), Cheetham; Janet K. (Laguna Niguel, CA), Kuan; Teresa H. (Placentia, CA), Power; David F. (Trabuco Canyon, CA)
Assignee:	Allergan, Inc. (Irvine, CA)
Application Number:	11/842,915
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,207,215
Patent Claims:	1. A method of controlling ocular postoperative inflammation or ocular postoperative pain comprising topically administering to said patient a composition comprising 0.4% w/v ketorolac tromethamine. 2. The method of claim 1 wherein said ocular postoperative pain is a result of photorefractive keratectomy surgery. 3. The method of claim 1 wherein said composition comprises 0.4% w/v ketorolac tromethamine, about 0.006% w/v benzalkonium chloride, about 0.015% w/v edetate disodium, about 0.003% w/v Octoxynol-40, and about 0.79% w/v sodium chloride. 4. The method of claim 3 wherein said composition comprises 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, and an effective amount of sodium hydroxide and hydrochloric acid to adjust the pH to a range of 7.2 to 7.6. 5. The method of claim 1 wherein said composition consists of 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, water and an effective amount of sodium hydroxide and hydrochloric acid to adjust the pH to a range of 7.2 to 7.6. 6. The method of claim 1 wherein said composition comprises 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, and an effective amount of sodium hydroxide or hydrochloric acid to adjust the pH. 7. The method of claim 1 wherein said composition consists essentially of 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, water and an effective amount of sodium hydroxide or hydrochloric acid to adjust the pH to a range of 7.2 to 7.6. 8. The method of claim 1 wherein said composition consists of 0.4% w/v ketorolac tromethamine, 0.006% w/v benzalkonium chloride, 0.015% w/v edetate disodium, 0.003% w/v Octoxynol-40, 0.79% w/v sodium chloride, water and an effective amount of sodium hydroxide or hydrochloric acid to adjust the pH. 9. The method of claim 1 wherein the method controls post-operative burning and stinging. 10. The method of claim 1 wherein the composition further comprises benzalkonium chloride. 11. The method of claim 1 wherein the composition further comprises about about 0.006% w/v benzalkonium chloride. 12. The method of claim 1 wherein the composition further comprises edetate disodium. 13. The method of claim 1 wherein the composition further comprises about 0.015% w/v edetate disodium. 14. The method of claim 1 wherein the composition further comprises Octoxynol-40. 15. The method of claim 1 wherein the composition further comprises about 0.003% w/v Octoxynol-40. 16. The method of claim 1 wherein the composition further comprises sodium chloride. 17. The method of claim 1 wherein the composition further comprises about 0.79% w/v sodium chloride. 18. The method of claim 1 wherein the composition has a pH of about 7.4.