Claims for Patent: 8,227,507

Summary for Patent: 8,227,507

Title:	Ligands that modulate RAR receptors
Abstract:	Novel ligand compounds having the general formula (I): ##STR00001## and pharmaceutical/cosmetic compositions comprised thereof are useful in human and veterinary medicine or, alternatively, in cosmetics.
Inventor(s):	Biadatti; Thibaud (Opio, FR), Dumais; Laurence (La Rouret, FR), Soulet; Catherine (Antibes, FR), Talano; Sandrine (Vence, FR), Daver; Sebastien (Antibes, FR)
Assignee:	Galderma Research & Development (Biot, FR)
Application Number:	12/842,347
Patent Claims:	1. A method for treating a dermatological condition selected from the group consisting of acne vulgaris, comedonic acne, polymorphic acne, nodulocystic acne, acne conglobata and secondary acne, said method comprising administering to an individual in need of such treatment, an effective amount of a pharmaceutical composition comprising a pharmaceutically effective amount of at least one ligand compound having the formula (I) below: ##STR00058## in which: R.sub.1 is a hydrogen atom, an alkyl radical of 1 to 4 carbon atoms or a --CF.sub.3 radical; R.sub.2 is a hydrogen atom, an alkyl or alkoxy radical of 1 to 4 carbon atoms or a chlorine atom; R.sub.3 is a hydrogen atom or a linear or branched alkyl or alkoxy radical of 1 to 10 carbon atoms optionally substituted with a methoxy group; R.sub.4 is a hydrogen atom or an alkyl radical of 1 to 3 carbon atoms; R.sub.5 is a hydrogen atom or an alkyl radical of 1 to 3 carbon atoms; or alternatively R.sub.4 and R.sub.5 form, together with the bond --N--C(.dbd.Y)--, a pyrrolidine, pyrrolidinone, piperidine or piperidinone ring; Y is two hydrogen atoms or a hetero atom; Ar is a 1,4-phenyl, 2,5-pyridyl, 5,2-pyridyl or 2,5-thiophenyl ring; X is an oxygen atom optionally substituted with an alkyl or alkylamine radical or a C--C single bond; and A is a hydrogen atom or the following formula: ##STR00059## in which: Q is an oxygen atom or an --NH-- bond; R.sub.6 is a hydrogen atom, an alkyl radical of 1 to 6 carbon atoms, a cycloalkyl radical of 3 to 6 carbon atoms or a --C(O)CH.sub.3 or --C(O)CH.sub.2CH.sub.3 radical; R.sub.7 and R.sub.7' represent, independently of each other, a hydrogen atom or a hydroxyl group, with the provisio that R.sub.7 and R.sub.7' are not simultaneously a hydroxyl group; and n is 0, 1, 2, 3, 4 or 5; or a salt of a compound of formula (I) when R.sub.3 is a hydrogen atom, or a geometrical isomer of a compound of formula (I); formulated into a pharmaceutically and physiologically acceptable medium therefor. 2. The method as defined by claim 1, wherein, in formula (I), R.sub.1 is a --CF.sub.3 radical. 3. The method as defined by claim 1, wherein, in formula (I), Ar is a 1,4-phenyl ring. 4. The method as defined by claim 1, wherein, in formula (I), Ar is a 2,5-pyridyl ring. 5. The method as defined by claim 1, wherein, in formula (I), Ar is a 5,2-pyridyl ring. 6. The method as defined by claim 1, wherein, in formula (I), Ar is a 2,5-thiophenyl ring. 7. The method as defined by claim 1, wherein, in formula (I), Y is oxygen. 8. The method as defined by claim 1, wherein, in formula (I), Y is sulfur. 9. The method as defined by claim 1, wherein, in formula (I), R.sub.4 and R.sub.5 together form, with the --N--C(.dbd.Y)-radical, a pyrrolidine, pyrrolidinone, piperidine or piperidinone ring. 10. The method as defined by claim 1, wherein the compound is an alkali metal or alkaline-earth metal salt, a zinc salt or a salt of an organic amine or of an acidic partner when the compound is itself basic. 11. The method as defined by claim 1, wherein the alkyl radical of 1 to 3 carbon atoms is selected from the group consisting of methyl, ethyl, i-propyl and n-propyl radicals. 12. The method as defined by claim 1, wherein the alkyl radical of 1 to 4 carbon atoms is selected from the group consisting of methyl, ethyl, i-propyl, i-butyl and t-butyl radicals. 13. The method as defined by claim 1, wherein the alkyl radical of 1 to 10 carbon atoms is selected from the group consisting of methyl, ethyl, propyl, i-propyl, butyl, i-butyl, t-butyl, pentyl, hexyl, heptyl, octyl, nonyl and dodecyl radicals. 14. The method as defined by claim 1, wherein the alkoxy radical having from 1 to 10 carbon atoms is selected from the group consisting of methoxy, ethoxy, isopropyloxy, tert-butoxy and hexyloxy radicals. 15. The method as defined by claim 1, wherein the alkoxy radical having from 1 to 4 carbon atoms is selected from the group consisting of methoxy, ethoxy, isopropyloxy and tert-butoxy radicals. 16. The method as defined by claim 1, wherein the cycloalkyl radical of 3 to 6 carbon atoms is selected from the group consisting of cyclopropyl, cyclopentyl and cyclohexyl radicals. 17. The method as defined by claim 1, wherein the ligand compound having formula (I) is selected from the group consisting of: 1. ethyl 3''-tert-butyl-4''-diethylamino-4'-hydroxy[1,1';3',1'']terphenyl-4-carbox- ylate, 2. ethyl 3''-tert-butyl-4''-diethylamino-4'-(4-hydroxybutoxy)-[1,1';3',1'']terphen- yl-4-carboxylate, 3. 3''-tert-butyl-4''-diethylamino-4'-(4-hydroxybutoxy)-[1,1';3',1'']terphen- yl-4-carboxylic acid, 4. ethyl 4''-(acetylethylamino)-3''-tert-butyl-4'-(4-hydroxybutoxy) -[1,1';3',1'']terphenyl-4-carboxylate, 5. 4''-(acetylethylamino)-3''-tert-butyl-4'-(4-hydroxybutoxy)-[1,1';3',1'']t- erphenyl-4-carboxylic acid, 6. 3''-tert-butyl-4''-diethylamino-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphen- yl-4-carboxylic acid, 7. ethyl 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphe- nyl -4-carboxylate, 8. 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphe- nyl-4-carboxylic acid, 9. ethyl 4''-diethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphenyl-4-carboxyla- te, 10. 4''-diethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphenyl-4-ca- rboxylic acid, 11. ethyl 4''-diethylamino-3''-ethyl-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphenyl-4- -carboxylate, 12. 4''-diethylamino-3''-ethyl-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphenyl-4- -carboxylic acid, 13. 4''-diethylamino-3''-ethyl-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphenyl-4-- carboxylic acid, 14. ethyl 4''-diethylamino-3''-ethyl-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphenyl-4-- carboxylate, 15. ethyl 3''-tert-butyl-4''-diethylamino-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphen- yl-4-carboxylate, 16. ethyl 4''-diethylamino-4'-(3-hydroxypropoxy)-3''-methyl[1,1';3',1'']terphenyl-4- -carboxylate, 17. 4''-diethylamino-4'-(3-hydroxypropoxy)-3''-methyl[1,1';3',1'']terphenyl-4- -carboxylic acid, 18. ethyl 3''-tert-butyl-4'-(4-hydroxybutoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylate, 19. 3''-tert-butyl-4'-(4-hydroxybutoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylic acid, 20. ethyl 4'-(4-hydroxybutoxy)-4''-pyrrolidin-1-yl-3''-trifluoromethyl[1,1';3',1'']- terphenyl-4-carboxylate, 21. 4'-(4-hydroxybutoxy)-4''-pyrrolidin-1-yl-3''-trifluoromethyl[1,1';3',1'']- terphenyl-4-carboxylic acid, 22. ethyl 3''-tert-butyl-4'-(3-hydroxypropoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terp- henyl -4-carboxylate, 23. 3''-tert-butyl-4'-(3-hydroxypropoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terp- henyl-4-carboxylic acid, 24. ethyl 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylate, 25. 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylic acid, 26. 4'-(3-hydroxypropoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terphenyl-4-carboxy- lic acid, 27. 3''-tert-butyl-4''-diethylamino-4'-hydroxy[1,1';3',1'']terphenyl-4-carbox- ylic acid, 28. ethyl 4''-diethylamino-4'-hydroxy-3''-trifluoromethyl[1,1';3',1'']terphenyl-4-c- arboxylate, 29. 4''-diethylamino-4'-hydroxy-3''-trifluoromethyl[1,1';3',1'']terphenyl-4-c- arboxylic acid, 30. 3''-tert-butyl-4''-diethylamino-4'-(4isopropylaminobutoxy)-[1,1';3',1'']t- erphenyl -4-carboxylic acid, 31. 3''-tert-butyl-4'-(4-isopropylaminobutoxy)-4''-pyrrolidin-1-yl[1,1';3',1'- ']terphenyl -4-carboxylic acid, 32. ethyl 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropyl)-[1,1';3',1'']terphen- yl-4-carboxylate, 33. 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropyl)-[1,1';3',1'']terphen- yl-4-carboxylic acid, 34. ethyl 3''-tert-butyl-4''-diethylamino-4'-(2,3-dihydroxypropyl) -[1,1';3',1'']terphenyl-4-carboxylate, 35. 3''-tert-butyl-4''-diethylamino-4'-(2,3-dihydroxypropyl)-[1,1';3',1'']ter- phenyl-4-carboxylic acid, 36. ethyl 4''-(acetylethylamino)-3''-tert-butyl-4'-(3-hydroxypropyl) -[1,1';3',1'']terphenyl-4-carboxylate, 37. 4''-(acetylethylamino)-3''-tert-butyl-4'-(3-hydroxypropyl)-[1,1';3',1'']t- erphenyl-4-carboxylic acid, 38. ethyl 3''-tert-butyl-4'-(3-cyclopropylaminopropyl)-4''-diethylamino[1,1';3',1''- ]terphenyl-4-carboxylate, 39. 3''-tert-butyl-4'-(3-cyclopropylaminopropyl)-4''-diethylamino[1,1';3',1''- ]terphenyl -4-carboxylic acid, 40. ethyl 3''-tert-butyl-4'-(3-cyclopentylaminopropyl)-4''-diethylamino[1,1';3',1''- ]terphenyl-4-carboxylate, 41. 3''-tert-butyl-4'-(3-cyclopentylaminopropyl)-4''-diethylamino[1,1';3',1''- ]terphenyl -4-carboxylic acid, 42. ethyl 3''-tert-butyl-4'-(3-cyclohexylaminopropyl)-4''-diethylamino[1,1';3',1'']- terphenyl-4-carboxylate, 43. 3''-tert-butyl-4'-(3-cyclohexylaminopropyl)-4''-diethylamino[1,1';3',1'']- terphenyl -4-carboxylic acid, 44. ethyl 3''-tert-butyl-4'-(3-tert-butylaminopropyl)-4''-diethylamino[1,1';3',1'']- terphenyl-4-carboxylate, 45. 3''-tert-butyl-4'-(3-tert-butylaminopropyl)-4''-diethylamino[1,1';3',1'']- terphenyl-4-carboxylic acid, 46. ethyl 4''-(acetylethylamino)-3''-tert-butyl-4'-(3-cyclopropylaminopropyl) -[1,1';3',1'']terphenyl-4-carboxylate, 47. 4''-(acetylethylamino)-3''-tert-butyl-4'-(3-cyclopropylaminopropyl) -[1,1';3',1'']terphenyl-4-carboxylic acid, 48. ethyl 3''-tert-butyl-4''-diethylamino-4'-(3-isopropylaminopropyl) -[1,1';3',1'']terphenyl-4-carboxylate, 49. 3''-tert-butyl-4''-diethylamino-4'-(3-isopropylaminopropyl)-[1,1';3',1'']- terphenyl -4-carboxylic acid, 50. ethyl 4'-(3-aminopropyl)-3''-tert-butyl-4''-diethylamino[1,1';3',1'']terphenyl-- 4-carboxylate, 51. 4'-(3-aminopropyl)-3''-tert-butyl-4''-diethylamino[1,1';3',1'']terphenyl-- 4-carboxylic acid, 52. [3''-tert-butyl-4-carboxy-4'-(3-hydroxypropyl)-[1,1';3',1'']terphenyl-4''- -yl]diethylamine hydrochloride, 53. 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-(2-oxopyrrolidin-1-yl)-[1,1';3',1- '']terphenyl -4-carboxylic acid, 54. 3''-tert-butyl-4''-ethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1'']terpheny- l-4-carboxylic acid, 55. 4'-(3-acetoxypropoxy)-3''-tert-butyl-4''-diethylamino[1,1';3',1'']terphen- yl-4-carboxylic acid, 56. 3''-tert-butyl-4''-diethylamino-4'-(3-propionyloxypropoxy)-[1,1';3',1'']t- erphenyl-4-carboxylic acid, 57. methyl 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy) -[1,1';3',1'']terphenyl-4-carboxylate, 58. isopropyl 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy) -[1,1';3',1'']terphenyl-4-carboxylate, 59. isobutyl 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy) -[1,1';3',1'']terphenyl-4-carboxylate, 60. 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy)-5''-methyl[1,1';3',- 1'']terphenyl-4-carboxylic acid, 61. 4''-diethylamino-4'-(3-hydroxypropoxy)-3''-isopropyl-5''-methyl[1,1';3',1- '']terphenyl-4-carboxylic acid, 62. 3''-tert-butyl-5''-chloro-4''-diethylamino-4'-(3-hydroxypropoxy) -[1,1';3',1'']terphenyl-4-carboxylic acid, 63. 4''-diethylamino-4'-(3-hydroxypropoxy)-3'',5''-diisopropyl[1,1';3',1'']te- rphenyl-4-carboxylic acid, 64. 3'',5''-di-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1''- ]terphenyl -4-carboxylic acid, 65. 4''-diethylamino-4'-(3-hydroxypropoxy)-3''-trifluoromethyl[1,1';3',1'']te- rphenyl-4-carboxylic acid, 66. 3''-tert-butyl-4''-(ethylmethylamino)-4'-(2-hydroxyethoxy)-[1,1';3',1'']t- erphenyl-4-carboxylic acid, 67. 3''-tert-butyl-4''-dimethylamino-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphe- nyl-4-carboxylic acid, 68. 3''-tert-butyl-4''-(ethylisopropylamino)-4'-(2-hydroxyethoxy) -[1,1';3',1'']terphenyl-4-carboxylic acid, 69. 3''-tert-butyl-4''-(ethylpropylamino)-4'-(2-hydroxyethoxy)-[1,1';3',1'']t- erphenyl-4-carboxylic acid, 70. 3''-tert-butyl-4''-dipropylamino-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphe- nyl-4-carboxylic acid, 71. 3''-tert-butyl-4''-(ethylpropionylamino)-4'-(2-hydroxyethoxy) -[1,1';3',1'']terphenyl-4-carboxylic acid, 72. 6-[3'-tert-butyl-4'-diethylamino-6-(2-hydroxyethoxy)biphenyl-3-yl]nicotin- ic acid, 73. 5-[3'-tert-butyl-4'-diethylamino-6-(2-hydroxyethoxy)biphenyl-3-yl]pyridin- e-2-carboxylic acid, 74. 5-[3'-tert-butyl-4'-diethylamino-6-(2-hydroxyethoxy)biphenyl-3-yl]thiophe- ne-2-carboxylic acid, 75. 3''-tert-butyl-4'-(2-hydroxyethoxy)-5''-methyl-4''-pyrrolidin-1-yl[1,1';3- ',1'']terphenyl-4-carboxylic acid, 76. 3''-tert-butyl-5''-chloro-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3- ',1'']terphenyl-4-carboxylic acid, 77. 4'-(2-hydroxyethoxy)-3''-isopropyl-4''-pyrrolidin-1-yl[1,1';3',1'']terphe- nyl-4-carboxylic acid, 78. 3''-ethyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terphenyl-- 4-carboxylic acid, 79. 4'-(2-hydroxyethoxy)-3'',5''-diisopropyl-4''-pyrrolidin-1-yl[1,1';3',1'']- terphenyl-4-carboxylic acid, 80. 3'',5''-diethyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terp- henyl-4-carboxylic acid, 81. 3'',5''-dimethyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']ter- phenyl-4-carboxylic acid, 82. 4'-(2-acetoxyethoxy)-3''-tert-butyl-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylic acid, 83. 4'-(2-propionyloxyethoxy)-3''-tert-butyl-4''-pyrrolidin-1-yl[1,1';3',1'']- terphenyl-4-carboxylic acid, 84. methyl 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl -4-carboxylate, 85. isopropyl 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylate, 86. isobutyl 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl -4-carboxylate, 87. ethyl 3''-tert-butyl-4'-(3-hydroxypropoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terp- henyl -4-carboxylate, 88. ethyl 3''-tert-butyl-5''-chloro-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3- ',1'']terphenyl-4-carboxylate, 89. 6-[3'-tert-butyl-6-(2-hydroxyethoxy)-4'-pyrrolidin-1-ylbiphenyl-3-yl]nico- tinic acid, 90. 5-[3'-tert-butyl-6-(2-hydroxyethoxy)-4'-pyrrolidin-1-ylbiphenyl-3-yl]pyri- dine-2-carboxylic acid, 91. ethyl 6-[3'-tert-butyl-6-(2-hydroxyethoxy)-4'-pyrrolidin-1-ylbiphenyl-3-yl]nico- tinate, 92. ethyl 3''-tert-butyl-4'-(3-hydroxypropyl)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylate, 93. 3''-tert-butyl-4'-(3-hydroxypropyl)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylic acid, 94. 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-(2-oxopyrrolidin-1-yl)-[1,1';3',1- '']terphenyl -4-carboxylic acid, 95. 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-(2-oxopiperid-1-yl)-[1,1';3',1'']- terphenyl-4-carboxylic acid, 96. 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-piperid-1-yl[1,1';3',1'']terpheny- l-4-carboxylic acid, and 97. 5-[3'-tert-butyl-6-(2-hydroxyethoxy)-4'-pyrrolidin-1-ylbiphenyl-3-yl]thio- phene-2-carboxylic acid. 18. The method as defined by claim 1, wherein, in formula (I), at least one of the following conditions is satisfied: R.sub.1 is a hydrogen atom or a t-butyl or i-propyl radical; R.sub.2 is a hydrogen atom or a t-butyl or i-propyl radical; R.sub.3 is a hydrogen atom or an ethyl radical; R.sub.4 and R.sub.5 are, independently of each other, a methyl or ethyl radical or together form a pyrrolidine ring; A is as defined in which R.sub.6 is a hydrogen atom, an i-propyl or t-butyl radical, a cycloalkyl radical of 3 to 6 carbon atoms or a --C(O)CH.sub.3 or --C(O)CH.sub.2CH.sub.3 radical. 19. The method as defined by claim 18, wherein, in formula (I), all of the following conditions are satisfied: R.sub.1 is a hydrogen atom or a t-butyl or i-propyl radical; R.sub.2 is a hydrogen atom or a t-butyl or i-propyl radical; R.sub.3 is a hydrogen atom or an ethyl radical; R.sub.4 and R.sub.5 are, independently of each other, a methyl or ethyl radical or together form a pyrrolidine ring; A is as defined in which R.sub.6 is a hydrogen atom, an i-propyl or t-butyl radical, a cycloalkyl radical of 3 to 6 carbon atoms or a --C(O)CH.sub.3 or --C(O)CH.sub.2CH.sub.3 radical. 20. The method as defined by claim 1, wherein the ligand compound having formula (I) is selected from the group consisting of: 3''-tert-butyl-4''-diethylamino-4'-(4-hydroxybutoxy)-[1,1';3',1'']terphen- yl-4-carboxylic acid, 4''-(acetylethylamino)-3''-tert-butyl-4'-(4-hydroxybutoxy)-[1,1';3',1'']t- erphenyl-4-carboxylic acid, 3''-tert-butyl-4''-diethylamino-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphen- yl-4-carboxylic acid, 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphe- nyl-4-carboxylic acid, 4''-diethylamino-3''-ethyl-4'-(3-hydroxypropoxy)-[1,1';3',1'']terphenyl-4- -carboxylic acid, 4''-diethylamino-3''-ethyl-4'-(2-hydroxyethoxy)-[1,1';3',1'']terphenyl-4-- carboxylic acid, 4''-diethylamino-4'-(3-hydroxypropoxy)-3''-methyl[1,1';3',1'']terphenyl-4- -carboxylic acid, 3''-tert-butyl-4'-(4-hydroxybutoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylic acid, 4'-(4-hydroxybutoxy)-4''-pyrrolidin-1-yl-3''-trifluoromethyl[1,1';3',1'']- terphenyl-4-carboxylic acid, 3''-tert-butyl-4'-(3-hydroxypropoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terp- henyl-4-carboxylic acid, 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylic acid, 3''-tert-butyl-4''-diethylamino-4'-(3-hydroxypropyl)-[1,1';3',1'']terphen- yl-4-carboxylic acid, 3''-tert-butyl-4''-diethylamino-4'-(2,3-dihydroxypropyl)-[1,1';3',1'']ter- phenyl-4-carboxylic acid, 4''-(acetylethylamino)-3''-tert-butyl-4'-(3-hydroxypropyl)-[1,1';3',1'']t- erphenyl-4-carboxylic acid, 4''-(acetylethylamino)-3''-tert-butyl-4'-(3-cyclopropylaminopropyl) -[1,1';3',1'']terphenyl-4-carboxylic acid, [3''-tert-butyl-4-carboxy-4'-(3-hydroxypropyl)-[1,1';3',1'']terphenyl-4''- -yl]diethylamine hydrochloride, 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-(2-oxopyrrolidin-1-yl)-[1,1';3',1- '']terphenyl-4-carboxylic acid, and 3''-tert-butyl-4''-ethylamino-4'-(3-hydroxypropoxy)-[1,1';3',1'']terpheny- l-4-carboxylic acid. 21. The regime or regimen as defined by claim 1, wherein the ligand compound having formula (I) is 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin-1-yl[1,1';3',1'']terph- enyl-4-carboxylic acid. 22. The method as defined by claim 1, wherein the individual is in need of treatment for acne vulgaris. 23. The method as defined by claim 2, wherein the ligand compound having formula (I) is 3''-tert-butyl-4'-(2-hydroxyethoxy)-4''-pyrrolidin -1-yl[1,1';3',1'']terphenyl-4-carboxylic acid.