Claims for Patent: 8,236,962

Summary for Patent: 8,236,962

Title:	Metalloenzyme inhibitor compounds
Abstract:	The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Inventor(s):	Hoekstra; William J. (Durham, NC), Schotzinger; Robert J. (Raleigh, NC), Rafferty; Stephen W. (Durham, NC)
Assignee:	Viamet Pharmaceuticals, Inc. (Morrisville, NC)
Application Number:	13/093,530
Patent Claims:	1. A compound of formula (I), or salt thereof, wherein: ##STR00032## MBG is optionally substituted tetrazolyl, optionally substituted triazolyl, or optionally substituted pyrazolyl; R.sub.1 is halo; R.sub.2 is halo; each R.sub.3 is independently alkyl, cyano, haloalkyl, alkoxy, halo, haloalkoxy, R.sub.4 is aryl optionally substituted with O, 1, 2 or 3 independent R.sub.3; R.sub.5 is H, or --C(O)alkyl optionally substituted with amino; n is 0, 1, 2 or 3. 2. The compound of claim 1, wherein R.sub.1 is fluoro. 3. The compound of claim 1, wherein R.sub.2 is fluoro. 4. The compound of claim 1, wherein R.sub.1 and R.sub.2 are fluoro. 5. The compound of claim 1, wherein R.sub.4 is phenyl optionally substituted with 0, 1, 2 or 3 independent R.sub.3. 6. The compound of claim 1, wherein R.sub.4 is phenyl optionally substituted with 0, 1, 2 or 3 independent halo. 7. The compound of claim 1, wherein R.sub.4 is phenyl optionally substituted with 0, 1, 2 or 3 independent fluoro. 8. The compound of claim 1, wherein R.sub.4 is 2,4-difluorophenyl. 9. The compound of claim 1, wherein R.sub.5 is H. 10. The compound of claim 1, wherein R.sub.5 is amino substituted acyl. 11. The compound of claim 1, wherein: R.sub.1 is fluoro; R.sub.2 is fluoro; R.sub.4 is 2,4-difluorophenyl; and R.sub.5 is H. 12. The compound of claim 1, wherein: each R.sub.3 is independently cyano, haloalkyl, alkoxy, halo, haloalkoxy, and n is 1 or 2. 13. The compound of claim 11, wherein: each R.sub.3 is independently cyano, haloalkyl, alkoxy, halo, haloalkoxy, and n is 1. 14. The compound of claim 1, which is one of: 4-(6-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)p- ropyl)pyridin-3-yl)benzonitrile (1); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(trifluoromethyl)phenyl)pyridin-2- -yl) propan-2-ol (2); 3-(6-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)p- ropyl)pyridin-3-yl)benzonitrile (3); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-isopropoxyphenyl)pyridin-2-yl- )-3-(1H-tetrazol-1-yl)propan-2-ol (4); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-fluorophenyl)pyridin-2-yl)-3-- (1H-tetrazol-1-yl)propan-2-ol (5); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(3-(trifluo- romethoxy)phenyl)pyridin-2-yl)propan-2-ol (6); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(trifluoromethoxy)phenyl)pyridin-- 2-yl) propan-2-ol (7); 1-(5-(3-Chlorophenyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-- (1H-tetrazol-1-yl)propan-2-ol (8); 1-(5-(4-Chlorophenyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-- (1H-tetrazol-1-yl)propan-2-ol (9); 2-(2,4-Difluorophenyl)-1-(5-(2,5-difluorophenyl)pyridin-2-yl)-1,1-difluor- o-3-(1H-tetrazol-1-yl)propan-2-ol (10); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-t- rifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol (11); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-(2,2,3,3,3-pentafluoropropoxy- )phenyl)pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol (12); 2-(2, 4-difluorophenyl)-1, 1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2, 2, 2-trifluoroethoxy)phenyl)pyridin-2-yl) propan-2-yl 3-aminopropanoate (13); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2- ,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-yl 2-aminoacetate hydrochloride (14); 2-(2,4-Difluorophenyl)-1, 1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoro methoxy)phenyl)pyridin-2-yl) propan-2-ol (15); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(4-fluorophenyl)pyridin-2-yl)-3-- (1H-1,2,4-triazol-1-yl)propan-2-ol (16); 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-1-(5-(4-(2,- 2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol (17); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-1-(5-(4-(tr- ifluoromethoxy)phenyl)pyridin-2-yl) propan-2-ol (18); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-1,2,3-triazol-1-yl)-1-(5-(4-(tr- ifluoromethoxy)phenyl)pyridin-2-yl) propan-2-ol (19); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-1-yl)-1-(5-(4-(2,2,2-t- rifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol (20); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(2H-tetrazol-1-yl)-1-(5-(3-(fluorophenyl)pyridin-2-yl) propan-2-ol (21); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(2H-tetrazol-1-yl)-1-(5-(4-(trifluoromethylphenyl)pyridin-2-- yl) propan-2-ol (22); 2-(2, 4-Difluorophenyl)-1, 1-difluoro-3-(1H-1,2,3-triazol-1-yl)-1-(5-(4-(trifluoromethylphenyl)pyrid- in-2-yl) propan-2-ol (23); 4-(6-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)p- ropyl)pyridin-3-yl)phenol (24); 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-(3-isopropylphenyl)pyridin-2-yl)- -3-(1H-tetrazol-1-yl)propan-2-ol (25); 2-(2,4-Difluorophenyl)-1-(5-(3,4-difluorophenyl)pyridin-2-yl)-1,1-difluor- o-3-(1H-tetrazol-1-yl)propan-2-ol (26); 1-(5-(3-(Difluoromethoxy)phenyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-- difluoro-3-(1H-tetrazol-1-yl)propan-2-ol (27); 2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-((triflu- oromethyl) thio)phenyl)pyridin-2-yl)propan-2-ol (28). 15. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.