Claims for Patent: 8,293,752

Summary for Patent: 8,293,752

Title:	Compounds useful as Raf kinase inhibitors
Abstract:	The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
Inventor(s):	Chen Weirong, Cossrow Jennifer, Franklin Lloyd, Guan Bing, Jones John Howard, Kumaravel Gnanasambandam, Lane Benjamin, Littke Adam, Lugovskoy Alexey, Peng Hairuo, Powell Noel, Raimundo Brian C., Tanaka Hiroko, Vessels Jeffrey, Wynn Thomas, Xin Zhili
Assignee:
Application Number:	US12164762
Patent Claims:	2. The compound according to claim 1 , wherein Ris —N(R).3. The compound according to claim 2 , wherein Ris —NH claim 2 , —NHCH claim 2 , —NHCHCH claim 2 , —NHCHCHCH claim 2 , —NHCH(CH) claim 2 , —NH(CH) claim 2 , —NHCHCHCHOH claim 2 , or —NHCHCHCHNH(CH).4. The compound according to claim 1 , wherein Ris hydrogen and Lis an optionally substituted claim 1 , straight or branched Calkylene chain.5. The compound according claim 1 , wherein Cyis an optionally substituted pyrrolyl claim 1 , pyrazolyl claim 1 , imidazolyl claim 1 , triazolyl claim 1 , thiophenyl claim 1 , furanyl claim 1 , thiazolyl claim 1 , isothiazolyl claim 1 , thiadiazolyl claim 1 , oxazolyl claim 1 , isoxazolyl claim 1 , or oxadiazolyl group.6. The compound according to claim 1 , wherein Lis —C(O)N(H)—.7. The compound according to claim 1 , wherein Cyis an optionally substituted group selected from pyridinyl claim 1 , pyrimidinyl claim 1 , pyrazinyl claim 1 , and pyridazinyl.10. A pharmaceutical composition comprising a compound according to claim 1 , and a pharmaceutically acceptable carrier claim 1 , adjuvant claim 1 , or vehicle.11. The composition of claim 10 , in combination with a therapeutic agent selected from a chemotherapeutic or anti-proliferative agent claim 10 , an anti-inflammatory agent claim 10 , an immunomodulatory agent claim 10 , a neurotrophic factor claim 10 , an agent for treating cardiovascular disease claim 10 , an agent for treating destructive bone disorders claim 10 , an agent for treating liver disease claim 10 , an anti-viral agent claim 10 , an agent for treating blood disorders claim 10 , an agent for treating diabetes claim 10 , and an agent for treating immunodeficiency disorders.13. A pharmaceutical composition comprising the compound of claim 12 , and a pharmaceutically acceptable carrier claim 12 , adjuvant claim 12 , or vehicle.