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Last Updated: December 22, 2024

Claims for Patent: 8,372,827

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Summary for Patent: 8,372,827

Title:	Therapeutic compositions
Abstract:	Ingenol angelate is a potent anticancer agent, and can be stabilized by dissolving it in an aprotic solvent in the presence of an acidic buffer.
Inventor(s):	Brown; Marc Barry (Watford, GB), Crowthers; Michael Edward Donald (Hillsborough, GB), Nazir; Tahir (Isleworth, GB)
Assignee:	LEO Laboratories Limted (Dublin, IE)
Application Number:	13/563,716
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,372,827
Patent Claims:	1. A pharmaceutical formulation for topical use in treatment of a subject, said pharmaceutical formulation comprising ingenol angelate in an amount from about 0.001% to about 0.15% w/w, wherein at least about 97.5% of the ingenol angelate is ingenol-3-angelate (isoform `b`) and said pharmaceutical formulation has a pH of less than 4. 2. The pharmaceutical formulation of claim 1 having a pH of about 3.5 or less. 3. The pharmaceutical formulation of claim 1 having a pH of about 3.0. 4. The pharmaceutical formulation of claim 1 having a pH within the range of about 2.5 to less than 4.0. 5. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a gel. 6. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a cream. 7. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is an ointment. 8. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a paint. 9. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a lotion. 10. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a foam. 11. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a transdermal patch. 12. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a sustained release formulation. 13. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is an emulsion. 14. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is an oil. 15. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation is a buccal formulation. 16. The pharmaceutical formulation of claim 1, wherein said pharmaceutical formulation further comprises a penetration enhancer, a preservative, a gelling agent or a buffer.

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