Claims for Patent: 8,377,880

Summary for Patent: 8,377,880

Title:	Therapeutic agents for reducing parathyroid hormone levels
Abstract:	Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X.sub.1--X.sub.2--X.sub.3--X.sub.4--X.sub.5--X.sub.6--X.sub.7, wherein the X.sub.1 subunit comprises a thiol-containing moiety and the distribution of charge on the X.sub.2--X.sub.7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.
Inventor(s):	Karim; Felix (Walnut Creek, CA), Baruch; Amos (San Francisco, CA), MacLean; Derek (Los Altos, CA), Das; Kanad (San Francisco, CA), Yin; Qun (Palo Alto, CA)
Assignee:	KAI Pharmaceuticals, Inc. (South San Francisco, CA)
Application Number:	13/365,213
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,377,880
Patent Claims:	1. A compound comprising Ac-c(C)arrrar-NH.sub.2 (SEQ ID NO:3). 2. A pharmaceutical composition comprising a compound comprising Ac-c(C)arrrar-NH.sub.2 (SEQ ID NO:3) and a pharmaceutically acceptable excipient.