Claims for Patent: 8,410,131

Summary for Patent: 8,410,131

Title:	Cancer treatment
Abstract:	Rapamycin derivatives have interesting effects in the treatment of solid tumors, optionally in combination with a chemotherapeutic agent.
Inventor(s):	Lane; Heidi (Basel, CH), O'Reilly; Terence (Basel, CH), Wood; Jeanette Marjorie (Biel-Benken, CH)
Assignee:	Novartis Pharmaceuticals Corporation (East Hanover, NJ)
Application Number:	10/468,520
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,410,131
Patent Claims:	1. A method for inhibiting growth of solid excretory system tumors in a subject, said method consisting of administering to said subject a therapeutically effective amount of a compound of formula I ##STR00002## wherein R.sub.1 is CH.sub.3, R.sub.2 is --CH.sub.2--CH.sub.2--OH, and X is .dbd.O. 2. The method of claim 1 wherein the solid excretory system tumor is an advanced solid excretory system tumor. 3. The method of claim 1 wherein the solid excretory system tumor is a kidney tumor. 4. The method of claim 1 wherein the solid excretory system tumor is a tumor of the renal pelvis. 5. The method of claim 1 wherein the compound of formula I is administered orally. 6. The method of claim 5 wherein the compound of formula I is administered at a daily dose range of from about 0.1 to 25 mg, as a single dose or in divided doses. 7. The method of claim 5 wherein the compound of formula I is administered in a unit dosage form of from about 0.05 to 12.5 mg. 8. The method of claim 5 wherein the compound of formula I is administered in a unit dosage form of from about 0.25 to 10 mg. 9. The method of claim 8 wherein the compound of formula I is administered in a unit dosage form of 10 mg.