Claims for Patent: 8,410,169

Summary for Patent: 8,410,169

Title:	Compounds and methods for delivery of prostacyclin analogs
Abstract:	This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have the following formula: ##STR00001##
Inventor(s):	Phares; Ken (Chapel Hill, NC), Mottola; David (Cary, NC)
Assignee:	United Therapeutics Corporation (Silver Spring, MD)
Application Number:	11/189,072
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,410,169
Patent Claims:	1. A therapeutic composition comprising a diethanolamine salt of treprostinil in combination with at least one additional cardiovascular agent selected from the group consisting of a calcium channel blocker, a phosphodiesterase inhibitor, and an endothelial antagonist. 2. A method of treating pulmonary hypertension comprising administering to a subject in need thereof an effective amount of a therapeutic composition comprising a diethanolamine salt of treprostinil in combination with at least one additional cardiovascular agent. 3. A method as claimed in claim 2, wherein the at least one additional cardiovascular agent is selected from the group consisting of a calcium channel blocker, a phosphodiesterase inhibitor, and an endothelial antagonist. 4. A composition comprising a therapeutically effective amount of treprostinil, wherein said composition is a liposome. 5. A liposome composition as claimed in claim 4, wherein the treprostinil is a diethanolamine salt of treprostinil. 6. A method of treating pulmonary hypertension comprising administering to a subject in need thereof an effective amount of the composition of claim 4. 7. A method as claimed in claim 6, wherein the treprostinil is a diethanolamine salt of treprostinil. 8. A pharmaceutical composition for oral administration comprising a therapeutically effective amount of a salt or ester of treprostinil, wherein said composition provides an oral bioavailability of treprostinil at least 50% greater than the oral bioavailability of a composition with treprostinil as a free acid. 9. The composition of claim 8, wherein said composition provides an oral bioavailability of treprostinil at least 100% greater than the oral bioavailability of a composition with treprostinil as a free acid. 10. The composition of claim 8, wherein the ester is selected from the group consisting of a benzyl ester and an amino acid ester. 11. The composition of claim 8, wherein the ester is selected from the group consisting of a benzyl ester and a diglycine ester.