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Last Updated: March 21, 2025

Claims for Patent: 8,497,258

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Summary for Patent: 8,497,258

Title:	Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
Abstract:	Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
Inventor(s):	Dohil Ranjan, Bastian John, Aceves Seema, Phillips Elaine, Hill Malcolm
Assignee:	The Regents of the University of California
Application Number:	US12269693
Patent Claims:	2. The method of claim 1 , wherein the pharmaceutical composition is a suspension comprising corticosteroid particles.3. The method of claim 1 , wherein the viscosity of the pharmaceutical composition is at least 10 cP at 25 degrees Celcius with a shear rate of about 13.2 sec.4. The method of claim 1 , wherein the pharmaceutical composition is administered once a day claim 1 , twice a day claim 1 , or three times a day.5. The method of claim 1 , wherein the pharmaceutical composition is administered no more than once a day.6. The method of claim 1 , wherein said corticosteroid is a topical corticosteroid.7. The method of claim 1 , wherein said corticosteroid is Budesonide.8. The method of claim 1 , wherein the viscosity enhancing excipient is selected from the group consisting of lactose claim 1 , sucrose claim 1 , sucralose claim 1 , maltodextrin claim 1 , dextrose claim 1 , mannitol claim 1 , sorbitol claim 1 , honey claim 1 , maize starch claim 1 , wheat starch claim 1 , rice starch claim 1 , potato starch claim 1 , gelatin claim 1 , gum tragacanth claim 1 , methyl cellulose claim 1 , hydroxypropylmethyl-cellulose claim 1 , a carboxymethyl cellulose (CMC) claim 1 , sodium carboxymethyl-cellulose (NaCMC) claim 1 , polyvinylpyrrolidone (PVP: povidone) claim 1 , and combinations thereof.9. The method of claim 1 , wherein the esophageal inflammation is eosinophilic esophagitis.10. The method of claim 1 , wherein 0.5-10 mg corticosteroid per day is administered to said individual.11. The method of claim 1 , wherein oral administration of the pharmaceutical composition provides a decreased systemic load of corticosteroid claim 1 , as measured by plasma AUC claim 1 , when compared to inhaled administration delivering an identical amount of corticosteroid.12. The method of claim 1 , wherein the pharmaceutical composition comprises corticosteroid particles claim 1 , wherein at least 95% of the corticosteroid particles have a diameter of less than 10 microns.13. The method of claim 1 , wherein said liquid vehicle comprises water.

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