Claims for Patent: 8,497,301

Summary for Patent: 8,497,301

Title:	Hydroxyl compounds and compositions for cholesterol management and related uses
Abstract:	The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
Inventor(s):	Dasseux; Jean-Louis Henri (Brighton, MI), Oniciu; Carmen Daniela (Ann Arbor, MI)
Assignee:	Esperion Therapeutics, Inc. (Plymouth, MI)
Application Number:	13/470,825
Patent Claims:	1. A method of lowering LDL levels, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula ##STR00100## or a pharmaceutically acceptable salt thereof. 2. The method of claim 1, wherein the method comprises administering to the patient a therapeutically effective amount of a compound of the formula ##STR00101##