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Last Updated: November 4, 2024

Claims for Patent: 8,598,186

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Summary for Patent: 8,598,186

Title:	CDK inhibitors
Abstract:	Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
Inventor(s):	Tavares; Francis X. (Durham, NC), Strum; Jay C. (Hillsborough, NC)
Assignee:	G1 Therapeutics, Inc. (Chapel Hill, NC)
Application Number:	13/869,520
Patent Claims:	1. A compound of the formula: ##STR00212## or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising an effective amount of the compound of claim 1 in a pharmaceutically acceptable carrier. 3. A compound of the formula: ##STR00213## or a pharmaceutically acceptable salt thereof. 4. A pharmaceutical composition comprising an effective amount of the compound of claim 3 in a pharmaceutically acceptable carrier. 5. A compound of the structure: ##STR00214## wherein R.sup.2 is -(alkylene).sub.m-heterocyclo or -(alkylene).sub.m-heteroaryl, R is hydrogen, and X is independently CH or N. 6. The compound of claim 5, wherein R.sup.2 is -(alkylene).sub.m-heterocyclo. 7. The compound of claim 5, wherein m is 0. 8. The compound of claim 6, wherein m is 0. 9. The compound of claim 5, wherein m is 1. 10. The compound of claim 6, wherein m is 1. 11. The compound of claim 5, wherein the heterocyclo is not substituted. 12. The compound of claim 6, wherein the heterocyclo is not substituted. 13. The compound of claim 5, wherein R.sup.2 is ##STR00215## 14. A pharmaceutical composition comprising an effective amount of the compound of claim 5 in a pharmaceutically acceptable carrier. 15. A compound of the structure: ##STR00216## wherein R.sup.2 is -(alkylene).sub.m-heterocyclo or -(alkylene).sub.m-heteroaryl, R is hydrogen, and X is independently CH or N. 16. The compound of claim 15, wherein R.sup.2 is -(alkylene).sub.m-heterocyclo. 17. The compound of claim 15, wherein m is 0. 18. The compound of claim 16, wherein m is 0. 19. The compound of claim 15, wherein m is 1. 20. The compound of claim 16, wherein m is 1. 21. The compound of claim 15, wherein the heterocyclo is not substituted. 22. The compound of claim 16, wherein the heterocyclo is not substituted. 23. The compound of claim 15, wherein R.sup.2 is ##STR00217## 24. A pharmaceutical composition comprising an effective amount of the compound of claim 15 in a pharmaceutically acceptable carrier.

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