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Last Updated: November 23, 2024

Claims for Patent: 8,642,760

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Summary for Patent: 8,642,760

Title:	Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Abstract:	The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous Aripiprazole crystals is stored for an extended period.
Inventor(s):	Bando; Takuji (Tokushima, JP), Aoki; Satoshi (Naruto, JP), Kawasaki; Junichi (Tokushima, JP), Ishigami; Makoto (Tokushima, JP), Taniguchi; Youichi (Tokushima, JP), Yabuuchi; Tsuyoshi (Tokushima, JP), Fujimoto; Kiyoshi (Naruto, JP), Nishioka; Yoshihiro (Tokushima, JP), Kobayashi; Noriyuki (Tokushima, JP), Fujimura; Tsutomu (Naruto, JP), Takahashi; Masanori (Tokushima, JP), Abe; Kaoru (Tokushima, JP), Nakagawa; Tomonori (Tokushima, JP), Shinhama; Koichi (Tokushima, JP), Utsumi; Naoto (Naruto, JP), Tominaga; Michiaki (Tokushima, JP), Ooi; Yoshihiro (Tokushima, JP), Yamada; Shohei (Tokushima, JP), Tomikawa; Kenji (Tokushima, JP)
Assignee:	Otsuka Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:	13/067,750
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,642,760
Patent Claims:	1. Aripiprazole drug substance of low hygroscopicity wherein said low hygroscopicity is defined as a moisture content of 0.40% or less after placing said drug substance for 24 hours in a dessicator maintained at a temperature of 60.degree. C. and a humidity level of 100%. 2. Aripiprazole drug substance of low hygroscopicity wherein said low hygroscopicity is defined as a moisture content of 0.10% or less after placing said drug substance for 24 hours in a dessicator maintained at a temperature of 60.degree. C. and a humidity level of 100%.

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