Claims for Patent: 8,679,545

Summary for Patent: 8,679,545

Title:	Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
Abstract:	Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
Inventor(s):	Dohil Ranjan, Bastian John, Aceves Seema
Assignee:
Application Number:	US12269572
Patent Claims:	2. The oral dosage form of claim 1 , wherein the excipient that increases the viscosity of the composition is maltodextrin.3. The oral dosage form of claim 1 , wherein the excipient that increases the viscosity of the composition is maltodextrin claim 1 , CMC claim 1 , or a combination thereof.5. The oral dosage form of claim 4 , comprising between about 0.1 g of maltodextrin per mL of liquid vehicle to about 0.6 g of maltodextrin per mL of liquid vehicle.6. The oral dosage form of claim 1 , wherein the oral dosage form is suitable for once a day administration.7. The oral dosage form of claim 1 , wherein the oral pharmaceutical composition is administered no more than once a day.8. The oral dosage form of claim 1 , comprising 0.25-5 mg of topically active corticosteroid.10. The oral dosage form of claim 1 , wherein the viscosity of the oral dosage form is nectar-like to honey-like.11. The oral dosage form of claim 1 , comprising 0.125-6 mg of topically active corticosteroid.12. The oral dosage form of claim 1 , wherein the liquid vehicle comprises water.13. The oral dosage form of claim 1 , wherein the excipient that increases the viscosity of the composition comprises CMC.14. The oral dosage form of claim 1 , wherein the oral dosage form has a volume of 10-25 mL.15. The oral dosage form of claim 1 , wherein the excipient that improves the palatability of the composition comprises a sweetening agent.16. The oral dosage form of claim 1 , wherein the sweetening agent comprises one or more of: lactose claim 1 , sucrose claim 1 , sucralose claim 1 , dextrose claim 1 , mannitol claim 1 , sorbitol claim 1 , honey claim 1 , maize starch claim 1 , wheat starch claim 1 , rice starch claim 1 , potato starch claim 1 , gelatin claim 1 , and gum tragacanth.18. The oral dosage form of claim 17 , wherein the second excipient that increases the viscosity of the composition is maltodextrin claim 17 , CMC claim 17 , or a combination thereof.19. The oral dosage form of comprising between about 0.1 g of maltodextrin per mL of liquid vehicle to about 0.6 g of maltodextrin per mL of liquid vehicle.20. The oral dosage form of claim 17 , wherein the viscosity of the oral dosage form is nectar-like to honey-like.21. The oral dosage form of claim 17 , comprising 0.125-6 mg of topically active corticosteroid.22. The oral dosage form of claim 17 , wherein the liquid vehicle comprises water.23. The oral dosage form of claim 17 , wherein the oral dosage form has a volume of 10-25 mL.