Claims for Patent: 8,741,327

Summary for Patent: 8,741,327

Title:	Method of maintaining therapeutic risperidone levels in a PLA:PLGA implant
Abstract:	The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
Inventor(s):	Siegel Steven, Winey Karen
Assignee:	The Trustees of the University of Pennsylvania
Application Number:	US11988137
Patent Claims:	2. The method of claim 1 , wherein said implant is a rod shaped structure.3. The method of claim 1 , wherein said therapeutic drug further comprises haloperidol.4. The method of claim 1 , wherein said implant has a surface area to volume ratio between 1 and 4 (millimeters [mm])/mm.5. The method of claim 1 , wherein said implant has a length between 3-45 millimeters.6. The method of claim 1 , wherein said implant has a diameter between 2-4 millimeters.7. The method of claim 1 , wherein said PLA:PGA molar ratio between 75:25 and 100:0.8. The method of claim 1 , wherein said therapeutic drug in said implant is capable of exhibiting the time to maximum concentration ranging from about 20 days to about 190 days after implanting said implant in a subject.