Claims for Patent: 8,785,420

Summary for Patent: 8,785,420

Title:	Combination/association of adapalene and benzoyl peroxide for treating acne lesions
Abstract:	Acne lesions, whether of inflammatory and/or non-inflammatory type, are simultaneously or sequentially treated and their number reduced, via daily topical regimen, with the combination or association of adapalene or pharmaceutically acceptable salt thereof and benzoyl peroxide (BPO).
Inventor(s):	Abou Chacra Vernet; Marie-Line (Nice, FR), Gross; Denis (Callian, FR), Loesche; Christian (Valbonne, FR), Poncet; Michel (Mougins, FR)
Assignee:	Galderma Research & Development (Biot, FR)
Application Number:	13/351,986
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,785,420
Patent Claims:	1. A regimen for the therapeutic treatment of acne lesions, the regimen comprising topically applying to the skin of a subject in need of said treatment, as active ingredients, 0.1% to 0.3% adapalene and 2.5% benzoyl peroxide, combined at fixed doses in a single formula that delivers said active ingredients together synergistically to achieve, in a group of such subjects, a degree of success of at least about 20%, wherein said single formula is applied once daily for a period of 12 weeks. 2. The regimen of claim 1, wherein the single formula is a gel. 3. A regimen for the therapeutic treatment of acne lesions, the regimen comprising topically applying to the skin of a subject in need of said treatment, as active ingredients, 0.1% to 0.3% adapalene and 2.5% benzoyl peroxide, combined at fixed doses in a single formula that delivers said active ingredients together synergistically to reduce the number of total acne lesions by at least 40%, wherein said single formula is applied once daily for a period of 12 weeks. 4. The regimen of claim 3, wherein the single formula is a gel. 5. A regimen for the therapeutic treatment of acne lesions, the regimen comprising topically applying to the skin of a subject in need of said treatment, as active ingredients, 0.1% to 0.3% adapalene and 2.5% benzoyl peroxide, combined at fixed doses in a single formula that delivers said active ingredients together synergistically to reduce the number of non-inflammatory acne lesions by at least 40%, wherein said single formula is a gel which is applied once daily for a period of 12 weeks. 6. A regimen for the therapeutic treatment of acne lesions, the regimen comprising topically applying to the skin of a subject in need of said treatment, as active ingredients, 0.1% to 0.3% adapalene and 2.5% benzoyl peroxide, combined at fixed doses in a single formula that delivers said active ingredients together synergistically to reduce the number of inflammatory acne lesions by at least 50%, wherein said single formula is a gel which is applied once daily for a period of 12 weeks. 7. A regimen for the therapeutic treatment of acne lesions, the regimen comprising topically applying to the skin of a subject in need of such treatment, as active ingredients, 0.1% to 0.3% adapalene and 2.5% benzoyl peroxide, combined at fixed doses in a single formula that delivers said active ingredients together synergistically to reduce the number of inflammatory lesions by at least 40%, wherein said single formula is applied once daily for a period of 12 weeks. 8. The regimen of claim 7, wherein the single formula is a gel. 9. A regimen for the therapeutic treatment of acne lesions, the regimen comprising topically applying to the skin of a subject in need of said treatment, as active ingredients, 0.1% to 0.3% adapalene and 2.5% benzoyl peroxide, combined at fixed doses in a single formula that delivers said active ingredients together synergistically to reduce the number of total acne lesions by at least 40%, to reduce the number of non-inflammatory acne lesions by at least 40%, to reduce the number of inflammatory acne lesions by at least 40% and to achieve in a group of such subjects, a degree of success of at least about 20%, wherein said single formula is applied once daily for a period of 12 weeks. 10. The regimen of claim 9, wherein the single formula is a gel. 11. A regimen for providing early onset of action in reducing total lesion counts in the therapeutic treatment of acne lesions, the regimen comprising topically applying to the skin of a subject in need of said treatment, as active ingredients, 0.1% to 0.3% adapalene and 2.5% benzoyl peroxide, combined at fixed doses in a single formula that delivers said active ingredients together, wherein said single formula is applied once daily for a period of 1, 2, or 4 weeks, and wherein the net reduction in total lesion counts in a group of such subjects, at week 1, week 2 or week 4, respectively, is numerically superior to the sum of the net reductions in total lesion counts achieved by the same dose of adapalene alone and of benzoyl peroxide alone at the corresponding time point. 12. The regimen of claim 11, wherein the single formula is a gel.