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Last Updated: December 28, 2024

Claims for Patent: 8,822,430

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Summary for Patent: 8,822,430

Title:	Antiviral compounds
Abstract:	The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Inventor(s):	Bacon; Elizabeth M. (Burlingame, CA), Canales; Eda (San Mateo, CA), Cho; Aesop (Mountain View, CA), Cottell; Jeromy J. (Redwood City, CA), Desai; Manoj C. (Pleasant Hill, CA), Graupe; Michael (Pacifica, CA), Guo; Hongyan (San Mateo, CA), Halcomb; Randall L. (Foster City, CA), Kato; Darryl (San Francisco, CA), Kim; Choung U. (San Carlos, CA), Kirschberg; Thorsten A. (Redwood City, CA), Krygowski; Evan S. (Belmont, CA), Lazerwith; Scott E. (San Francisco, CA), Link; John O. (San Francisco, CA), Liu; Hongtao (Foster City, CA), Liu; Qi (Union City, CA), Mackman; Richard L. (Millbrae, CA), Mitchell; Michael L. (Heyward, CA), Parrish; Jay P. (Redwood City, CA), Pyun; Hyung-Jung (Fremont, CA), Saugier; Joseph H. (Livermore, CA), Schroeder; Scott D. (Foster City, CA), Sun; Jianyu (Surrey, CA), Taylor; James G. (San Mateo, CA), Trenkle; James D. (Oakland, CA), Tse; Winston C. (Redwood City, CA), Vivian; Randall W. (San Mateo, CA), Watkins; William J. (Saratoga, CA), Xu; Lianhong (Palo Alto, CA)
Assignee:	Gilead Pharmasset LLC (Foster City, CA)
Application Number:	13/956,195
Patent Claims:	1. A compound of formula: ##STR01308## wherein: V is alkyl; L is benzimidazolyl; M is a 5-membered heteroaryl ring; P is selected from: ##STR01309## and R''' is hydrogen or methyl. 2. The compound of claim 1 that is: ##STR01310## 3. The compound of claim 1 that is: ##STR01311## 4. The compound of claim 1 wherein P is selected from: ##STR01312## 5. The compound of claim 1 wherein P is ##STR01313## 6. The compound of claim 1 wherein P is ##STR01314## 7. The compound of claim 1 that is: ##STR01315## 8. The compound of claim 1 that is: ##STR01316## 9. A compound: ##STR01317## wherein: V is alkyl; and M is a 5-membered heteroaryl ring. 10. A compound: ##STR01318## wherein: V is alkyl. 11. The compound of claim 1 wherein each V is: ##STR01319## 12. A compound of formula: ##STR01320## 13. A compound of formula: ##STR01321## 14. A pharmaceutical composition comprising the compound as described in claim 1 and at least one pharmaceutically acceptable carrier. 15. A pharmaceutical composition comprising a compound of formula: ##STR01322## and at least one pharmaceutically acceptable carrier. 16. A method of inhibiting HCV in a human comprising administering a compound of claim 1. 17. A method of inhibiting HCV in a human comprising administering a compound of formula: ##STR01323##

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