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Last Updated: December 28, 2024

Claims for Patent: 8,835,488


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Summary for Patent: 8,835,488
Title:Opioid receptor ligands and methods of using and making same
Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
Inventor(s): Yamashita; Dennis (Wayne, PA), Gotchev; Dimitar (Hatboro, PA), Pitis; Philip (North Wales, PA), Chen; Xiao-Tao (Furlong, PA), Liu; Guodong (Jamison, PA), Yuan; Catherine C. K. (King of Prussia, PA)
Assignee: Trevena, Inc. (King of Prussia, PA)
Application Number:13/428,849
Patent Claims: 1. A compound having the formula ##STR00226##

2. A pharmaceutical composition comprising a compound of claim 1 and pharmaceutically acceptable carrier.

3. The pharmaceutical composition of claim 2 further comprising at least one additional anti-constipation agent.

4. A compound, having the formula ##STR00227##

5. The pharmaceutical composition of claim 2 further comprising at least one additional analgesic or non-opioid analgesic.

6. A pharmaceutical composition comprising a compound of claim 4 and pharmaceutically acceptable carrier.

7. A method of treating pain comprising administering to a subject in need thereof a compound of claim 4.

8. The method of claim 7, wherein the compound is co-administered simultaneously or sequentially with an additional analgesic or non-opioid analgesic.

9. The method of claim 7, wherein the compound is co-administered simultaneously or sequentially with an anti-constipation agent.

10. The pharmaceutical composition of claim 6 further comprising at least one additional analgesic or non-opioid analgesic.

11. The pharmaceutical composition of claim 6 further comprising at least one anti-constipation agent.

12. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 90% of ##STR00228##

13. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 95% of ##STR00229##

14. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 98% of ##STR00230##

15. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 99% of ##STR00231##

16. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 6.

17. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 10.

18. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 11.

19. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 12.

20. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 13.

21. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 14.

22. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 15.

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