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Last Updated: November 25, 2024

Claims for Patent: 8,835,488

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Summary for Patent: 8,835,488

Title:	Opioid receptor ligands and methods of using and making same
Abstract:	This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
Inventor(s):	Yamashita; Dennis (Wayne, PA), Gotchev; Dimitar (Hatboro, PA), Pitis; Philip (North Wales, PA), Chen; Xiao-Tao (Furlong, PA), Liu; Guodong (Jamison, PA), Yuan; Catherine C. K. (King of Prussia, PA)
Assignee:	Trevena, Inc. (King of Prussia, PA)
Application Number:	13/428,849
Patent Claims:	1. A compound having the formula ##STR00226## 2. A pharmaceutical composition comprising a compound of claim 1 and pharmaceutically acceptable carrier. 3. The pharmaceutical composition of claim 2 further comprising at least one additional anti-constipation agent. 4. A compound, having the formula ##STR00227## 5. The pharmaceutical composition of claim 2 further comprising at least one additional analgesic or non-opioid analgesic. 6. A pharmaceutical composition comprising a compound of claim 4 and pharmaceutically acceptable carrier. 7. A method of treating pain comprising administering to a subject in need thereof a compound of claim 4. 8. The method of claim 7, wherein the compound is co-administered simultaneously or sequentially with an additional analgesic or non-opioid analgesic. 9. The method of claim 7, wherein the compound is co-administered simultaneously or sequentially with an anti-constipation agent. 10. The pharmaceutical composition of claim 6 further comprising at least one additional analgesic or non-opioid analgesic. 11. The pharmaceutical composition of claim 6 further comprising at least one anti-constipation agent. 12. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 90% of ##STR00228## 13. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 95% of ##STR00229## 14. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 98% of ##STR00230## 15. The pharmaceutical composition of claim 6, wherein the pharmaceutical composition comprises an enantiomeric excess of at least 99% of ##STR00231## 16. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 6. 17. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 10. 18. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 11. 19. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 12. 20. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 13. 21. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 14. 22. A method of treating pain comprising administering to a subject in need thereof the pharmaceutical composition of claim 15.

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