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Last Updated: April 5, 2025

Claims for Patent: 8,841,446

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Summary for Patent: 8,841,446

Title:	Medicaments containing vardenafil hydrochloride trihydrate
Abstract:	The invention relates to a method for producing medicaments that contain vardenafil hydrochloride, essentially as trihydrate in solid form, and to medicaments that can be obtained according to this method.
Inventor(s):	Serno; Peter (Gladbach, DE), Grunenberg; Alfons (Dormagen, DE), Ohm; Andreas (Neuss, DE), Bellinghausen; Rainer (Odenthal, DE), Vollers; Elmer (Leverkusen, DE), Henck; Jan-Olav (Willich, DE)
Assignee:	Bayer Intellectual Property GmbH (Monheim, DE)
Application Number:	13/625,481
Patent Claims:	1. A coated tablet comprising 0.1-70% by weight vardenafil hydrochloride, primarily in the form of vardenafil hydrochloride trihydrate, 0.1-10% by weight disintegrant, 0.1-2% by weight lubricant, and fillers as remaining ingredients, characterized in that the vardenafil hydrochloride trihydrate content of the vardenafil hydrochloride is at least 90 mol %. 2. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler. 3. A coated tablet as claimed in claim 1 comprising crospovidone as disintegrant. 4. A coated tablet as claimed in claim 1 comprising magnesium stearate as lubricant. 5. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant and magnesium stearate as lubricant. 6. A coated tablet as claimed in claim 1 comprising 4% by weight vardenafil hydrochloride trihydrate. 7. A coated tablet as claimed in claim 1 comprising 7% by weight vardenafil hydrochloride trihydrate. 8. A coated tablet as claimed in claim 1 comprising 9% by weight vardenafil hydrochloride trihydrate. 9. A coated tablet as claimed in claim 1 comprising 13% by weight vardenafil hydrochloride trihydrate. 10. A coated tablet as claimed in claim 1 comprising 5% by weight crospovidone. 11. A coated tablet as claimed in claim 1 comprising 1% by weight magnesium stearate. 12. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 4% by weight vardenafil hydrochloride trihydrate. 13. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 7% by weight vardenafil hydrochloride trihydrate. 14. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 9% by weight vardenafil hydrochloride trihydrate. 15. A coated tablet as claimed in claim 1 comprising microcrystalline cellulose as filler, crospovidone as disintegrant, magnesium stearate as lubricant and 13% by weight vardenafil hydrochloride trihydrate.

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